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Slc29a2 solute carrier family 29 (nucleoside transporters), member 2 [ Mus musculus (house mouse) ]

Gene ID: 13340, updated on 18-Apr-2024

Summary

Official Symbol
Slc29a2provided by MGI
Official Full Name
solute carrier family 29 (nucleoside transporters), member 2provided by MGI
Primary source
MGI:MGI:1345278
See related
Ensembl:ENSMUSG00000024891 AllianceGenome:MGI:1345278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ent2; Der12; Hnp36; mENT2
Summary
Enables neurotransmitter transmembrane transporter activity and purine nucleoside transmembrane transporter activity. Involved in adenosine transport; neurotransmitter uptake; and purine nucleoside transmembrane transport. Acts upstream of or within nucleoside transport. Is active in plasma membrane. Orthologous to human SLC29A2 (solute carrier family 29 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 8.0), heart adult (RPKM 7.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
19 A; 19 4.23 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5069085..5082000)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5019057..5031972)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45370 Neighboring gene mitochondrial ribosomal protein L11 Neighboring gene neuronal PAS domain protein 4 Neighboring gene nuclear encoded tRNA serine 6 (anticodon GCT) Neighboring gene predicted gene, 30581 Neighboring gene beta-1,4-glucuronyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables cytidine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables guanine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables neurotransmitter transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleobase transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleoside transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleoside transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleoside transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables purine nucleoside transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables purine nucleoside transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables uracil transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables uridine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables uridine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adenine transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in adenosine transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in adenosine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cytidine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in guanine transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in guanine transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in guanine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in hypoxanthine transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hypoxanthine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in inosine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter transport ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter uptake IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nucleobase transport ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleoside transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleoside transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nucleoside transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleoside transport ISO
Inferred from Sequence Orthology
more info
 
involved_in purine nucleobase transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in purine nucleoside transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in purine nucleoside transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in pyrimidine-containing compound transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in thymine transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in thymine transport ISO
Inferred from Sequence Orthology
more info
 
involved_in uracil transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in uridine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in uridine transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in uridine transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
equilibrative nucleoside transporter 2
Names
36 kDa hydrophobic nucleolar protein
36 kDa nucleolar protein HNP36
delayed early response gene 12
delayed-early response protein 12
equilibrative NBMPR-insensitive nucleoside transporter
equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter
nucleoside transporter, ei-type
solute carrier family 29 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007854.3NP_031880.2  equilibrative nucleoside transporter 2

    See identical proteins and their annotated locations for NP_031880.2

    Status: VALIDATED

    Source sequence(s)
    BC048958, BF465335
    Consensus CDS
    CCDS50354.1
    UniProtKB/Swiss-Prot
    Q61672, Q9JIT8
    Related
    ENSMUSP00000157780.2, ENSMUST00000236152.2
    Conserved Domains (1) summary
    TIGR00939
    Location:18456
    2a57; Equilibrative Nucleoside Transporter (ENT)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    5069085..5082000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250738.1XP_030106598.1  equilibrative nucleoside transporter 2 isoform X1

    UniProtKB/TrEMBL
    A0A494BAC3
    Conserved Domains (1) summary
    TIGR00939
    Location:6404
    2a57; Equilibrative Nucleoside Transporter (ENT)
  2. XM_030250739.2XP_030106599.1  equilibrative nucleoside transporter 2 isoform X1

    UniProtKB/TrEMBL
    A0A494BAC3
    Related
    ENSMUSP00000157983.2, ENSMUST00000237371.2
    Conserved Domains (1) summary
    TIGR00939
    Location:6404
    2a57; Equilibrative Nucleoside Transporter (ENT)

RNA

  1. XR_003952750.1 RNA Sequence