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PDCL2 phosducin like 2 [ Homo sapiens (human) ]

Gene ID: 132954, updated on 11-Apr-2024

Summary

Official Symbol
PDCL2provided by HGNC
Official Full Name
phosducin like 2provided by HGNC
Primary source
HGNC:HGNC:29524
See related
Ensembl:ENSG00000163440 MIM:611676; AllianceGenome:HGNC:29524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCPHLP
Summary
This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 13.2) See more
Orthologs
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Genomic context

See PDCL2 in Genome Data Viewer
Location:
4q12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (55556519..55592245, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (59044647..59080385, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (56422686..56458412, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene clock circadian regulator Neighboring gene uncharacterized LOC124900704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15442 Neighboring gene RN7SK pseudogene 30 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15443 Neighboring gene neuromedin U Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:56501035-56501786 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:56501787-56502538 Neighboring gene uncharacterized LOC105377660

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in acrosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sperm axoneme assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152401.3NP_689614.2  phosducin-like protein 2

    See identical proteins and their annotated locations for NP_689614.2

    Status: REVIEWED

    Source sequence(s)
    AC024243, AW629089, BC034431, BG198696
    Consensus CDS
    CCDS47059.1
    UniProtKB/Swiss-Prot
    A8MWA2, B9ZVQ9, Q8N4E4
    Related
    ENSP00000295645.4, ENST00000295645.9
    Conserved Domains (1) summary
    cd02988
    Location:8200
    Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    55556519..55592245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265728.4XP_005265785.1  phosducin-like protein 2 isoform X3

    Conserved Domains (1) summary
    cl00388
    Location:8120
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. XM_011534374.3XP_011532676.1  phosducin-like protein 2 isoform X1

    Conserved Domains (1) summary
    cd02988
    Location:6168
    Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...
  3. XM_047449616.1XP_047305572.1  phosducin-like protein 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    59044647..59080385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348945.1XP_054204920.1  phosducin-like protein 2 isoform X3

  2. XM_054348943.1XP_054204918.1  phosducin-like protein 2 isoform X1

  3. XM_054348944.1XP_054204919.1  phosducin-like protein 2 isoform X2