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CORT cortistatin [ Homo sapiens (human) ]

Gene ID: 1325, updated on 1-Jun-2020

Summary

Official Symbol
CORTprovided by HGNC
Official Full Name
cortistatinprovided by HGNC
Primary source
HGNC:HGNC:2257
See related
Ensembl:ENSG00000241563 MIM:602784
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CST-14; CST-17; CST-29
Summary
This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]
Expression
Biased expression in brain (RPKM 6.6), testis (RPKM 2.0) and 1 other tissue See more
Orthologs

Genomic context

See CORT in Genome Data Viewer
Location:
1p36.22
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (10450031..10451998)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (10509776..10512060)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphogluconate dehydrogenase Neighboring gene CENPS-CORT readthrough Neighboring gene centromere protein S Neighboring gene DNA fragmentation factor subunit alpha Neighboring gene peroxisomal biogenesis factor 14 Neighboring gene RNA, 7SL, cytoplasmic 614, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough CENPS-CORT

Readthrough gene: CENPS-CORT, Included gene: CENPS

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NOT Fanconi anaemia nuclear complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cortistatin
Names
cortistatin-14
cortistatin-17
cortistatin-29
prepro-cortistatin
preprocortistatin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302.5NP_001293.3  cortistatin preproprotein

    See identical proteins and their annotated locations for NP_001293.3

    Status: REVIEWED

    Source sequence(s)
    AY358561, BC040034, BC119724, BF590359
    Consensus CDS
    CCDS117.2
    UniProtKB/Swiss-Prot
    O00230
    UniProtKB/TrEMBL
    Q8IUV6
    Related
    ENSP00000366248.3, ENST00000377049.3
    Conserved Domains (1) summary
    pfam03002
    Location:87104
    Somatostatin; Somatostatin/Cortistatin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    10450031..10451998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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