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SMIM43 small integral membrane protein 43 [ Homo sapiens (human) ]

Gene ID: 132332, updated on 1-Mar-2024

Summary

Official Symbol
SMIM43provided by HGNC
Official Full Name
small integral membrane protein 43provided by HGNC
Primary source
HGNC:HGNC:55077
See related
Ensembl:ENSG00000164112 AllianceGenome:HGNC:55077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEMEP; TMEM155
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 10.6), placenta (RPKM 2.0) and 1 other tissue See more
Orthologs
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Genomic context

See SMIM43 in Genome Data Viewer
Location:
4q27
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (121758930..121765400, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (125062956..125069427, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122680085..122686555, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377402 Neighboring gene annexin A5 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:122611545-122612744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15659 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:122633152-122634351 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15660 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:122669697-122670300 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:122670301-122670904 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_72694 Neighboring gene uncharacterized LOC100192379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21868 Neighboring gene Sharpr-MPRA regulatory region 4891 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:122721667-122722470 Neighboring gene exosome component 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21871 Neighboring gene cyclin A2 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21872

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
small integral membrane protein 43
Names
Nodal Enhanced MEsendoderm Peptide
protein TMEM155
transmembrane protein 155

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384332.1NP_001371261.1  small integral membrane protein 43

    Status: VALIDATED

    Source sequence(s)
    AC079341
    Consensus CDS
    CCDS93616.1
    UniProtKB/Swiss-Prot
    A0A2R8YEN4, D3DNW9, Q4W5P6, Q96NI2
    Related
    ENSP00000495721.1, ENST00000643802.2
  2. NM_001384333.1NP_001371262.1  small integral membrane protein 43

    Status: VALIDATED

    Source sequence(s)
    AC079341
    Consensus CDS
    CCDS93616.1
    UniProtKB/Swiss-Prot
    A0A2R8YEN4, D3DNW9, Q4W5P6, Q96NI2
  3. NM_001384334.1NP_001371263.1  small integral membrane protein 43

    Status: VALIDATED

    Source sequence(s)
    AC079341
    Consensus CDS
    CCDS93616.1
    UniProtKB/Swiss-Prot
    A0A2R8YEN4, D3DNW9, Q4W5P6, Q96NI2
    Related
    ENST00000461198.5

RNA

  1. NR_169194.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079341
    Related
    ENST00000394396.5
  2. NR_169195.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079341
  3. NR_169196.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079341

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    121758930..121765400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    125062956..125069427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348898.1XP_054204873.1  small integral membrane protein 43 isoform X1

    UniProtKB/Swiss-Prot
    A0A2R8YEN4, D3DNW9, Q4W5P6, Q96NI2
  2. XM_054348897.1XP_054204872.1  small integral membrane protein 43 isoform X1

    UniProtKB/Swiss-Prot
    A0A2R8YEN4, D3DNW9, Q4W5P6, Q96NI2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001317837.2: Suppressed sequence

    Description
    NM_001317837.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  2. NM_001317838.2: Suppressed sequence

    Description
    NM_001317838.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  3. NM_001317839.2: Suppressed sequence

    Description
    NM_001317839.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  4. NM_001317841.2: Suppressed sequence

    Description
    NM_001317841.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  5. NM_001317842.2: Suppressed sequence

    Description
    NM_001317842.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  6. NM_001369019.1: Suppressed sequence

    Description
    NM_001369019.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  7. NM_152399.4: Suppressed sequence

    Description
    NM_152399.4: This RefSeq was removed because currently there is support for the transcript but not for the protein.