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PPM1M protein phosphatase, Mg2+/Mn2+ dependent 1M [ Homo sapiens (human) ]

Gene ID: 132160, updated on 22-Jun-2021

Summary

Official Symbol
PPM1Mprovided by HGNC
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1Mprovided by HGNC
Primary source
HGNC:HGNC:26506
See related
Ensembl:ENSG00000164088 MIM:608979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP2CE; PP2Ceta; PP2C-eta
Expression
Ubiquitous expression in lymph node (RPKM 16.5), spleen (RPKM 14.7) and 25 other tissues See more
Orthologs
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Genomic context

See PPM1M in Genome Data Viewer
Location:
3p21.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (52245725..52250599)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52279775..52284615)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene twinfilin actin binding protein 2 Neighboring gene TWF2 divergent transcript Neighboring gene WD repeat domain 82 Neighboring gene microRNA let-7g Neighboring gene uncharacterized LOC107986086 Neighboring gene glycerate kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.
GeneReviews: Not available
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32332

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein phosphatase 1M
Names
protein phosphatase 1M (PP2C domain containing)
protein phosphatase 2C eta-2
NP_001116342.1
NP_653242.3
XP_005264936.1
XP_005264937.1
XP_005264938.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122870.3NP_001116342.1  protein phosphatase 1M isoform b

    See identical proteins and their annotated locations for NP_001116342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AA829740, AC006252, BC009644, DA869388
    Consensus CDS
    CCDS46840.1
    UniProtKB/Swiss-Prot
    Q96MI6
    Related
    ENSP00000387046.3, ENST00000409502.7
    Conserved Domains (1) summary
    cd00143
    Location:2237
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  2. NM_144641.4NP_653242.3  protein phosphatase 1M isoform a

    See identical proteins and their annotated locations for NP_653242.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA829740, AB474372, AC006252, BC009644, BF516133, DB479638
    UniProtKB/Swiss-Prot
    Q96MI6
    UniProtKB/TrEMBL
    B7XGB9
    Related
    ENSP00000319894.5, ENST00000323588.9
    Conserved Domains (1) summary
    cd00143
    Location:118449
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    52245725..52250599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264879.2XP_005264936.1  protein phosphatase 1M isoform X1

    Conserved Domains (1) summary
    cd00143
    Location:118410
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  2. XM_005264880.3XP_005264937.1  protein phosphatase 1M isoform X2

    Conserved Domains (1) summary
    cd00143
    Location:113364
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
  3. XM_005264881.1XP_005264938.1  protein phosphatase 1M isoform X3

    See identical proteins and their annotated locations for XP_005264938.1

    Conserved Domains (1) summary
    cd00143
    Location:24288
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RNA

  1. XR_001740024.1 RNA Sequence

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