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Ddc dopa decarboxylase [ Mus musculus (house mouse) ]

Gene ID: 13195, updated on 17-Jan-2023

Summary

Official Symbol
Ddcprovided by MGI
Official Full Name
dopa decarboxylaseprovided by MGI
Primary source
MGI:MGI:94876
See related
Ensembl:ENSMUSG00000020182 AllianceGenome:MGI:94876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aadc
Summary
Enables aromatic-L-amino-acid decarboxylase activity. Acts upstream of or within response to toxic substance. Located in cytoplasm. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and sensory organ. Used to study aromatic L-amino acid decarboxylase deficiency. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and inherited metabolic disorder. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 29.2), liver adult (RPKM 20.2) and 16 other tissues See more
Orthologs
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Genomic context

See Ddc in Genome Data Viewer
Location:
11 A1; 11 7.09 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (11764101..11848144, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (11814101..11898144, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11999 Neighboring gene IKAROS family zinc finger 1 Neighboring gene fidgetin-like 1 Neighboring gene RIKEN cDNA 1700042O10 gene Neighboring gene predicted gene, 51937 Neighboring gene predicted gene, 25058 Neighboring gene VISTA enhancer mm154 Neighboring gene growth factor receptor bound protein 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-dopa decarboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables aromatic-L-amino-acid decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aromatic-L-amino-acid decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aromatic-L-amino-acid decarboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables carbon-carbon lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within catecholamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in catecholamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in serotonin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in serotonin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aromatic-L-amino-acid decarboxylase
NP_001177377.1
NP_057881.1
XP_006514550.1
XP_006514551.1
XP_036012174.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190448.1NP_001177377.1  aromatic-L-amino-acid decarboxylase

    See identical proteins and their annotated locations for NP_001177377.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL596450, AL645803
    Consensus CDS
    CCDS24439.1
    UniProtKB/Swiss-Prot
    O88533
    UniProtKB/TrEMBL
    Q5SUV8
    Related
    ENSMUSP00000136467.2, ENSMUST00000178704.8
    Conserved Domains (1) summary
    pfam00282
    Location:35414
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
  2. NM_016672.4NP_057881.1  aromatic-L-amino-acid decarboxylase

    See identical proteins and their annotated locations for NP_057881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA986109, AK149141, BY129740
    Consensus CDS
    CCDS24439.1
    UniProtKB/Swiss-Prot
    O88533
    UniProtKB/TrEMBL
    Q5SUV8
    Related
    ENSMUSP00000105286.3, ENSMUST00000109659.9
    Conserved Domains (1) summary
    pfam00282
    Location:35414
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    11764101..11848144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514488.5XP_006514551.1  aromatic-L-amino-acid decarboxylase isoform X1

    See identical proteins and their annotated locations for XP_006514551.1

    UniProtKB/Swiss-Prot
    O88533
    UniProtKB/TrEMBL
    Q5SUV8
    Conserved Domains (1) summary
    pfam00282
    Location:35414
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
  2. XM_006514487.5XP_006514550.1  aromatic-L-amino-acid decarboxylase isoform X1

    See identical proteins and their annotated locations for XP_006514550.1

    UniProtKB/Swiss-Prot
    O88533
    UniProtKB/TrEMBL
    Q5SUV8
    Conserved Domains (1) summary
    pfam00282
    Location:35414
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
  3. XM_036156281.1XP_036012174.1  aromatic-L-amino-acid decarboxylase isoform X1

    UniProtKB/Swiss-Prot
    O88533
    UniProtKB/TrEMBL
    Q5SUV8
    Conserved Domains (1) summary
    pfam00282
    Location:35414
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain