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Dctn1 dynactin 1 [ Mus musculus (house mouse) ]

Gene ID: 13191, updated on 18-Apr-2024

Summary

Official Symbol
Dctn1provided by MGI
Official Full Name
dynactin 1provided by MGI
Primary source
MGI:MGI:107745
See related
Ensembl:ENSMUSG00000031865 AllianceGenome:MGI:107745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p150; Glued; DP-150; DAP-150; p150-glued; p150<glued>
Summary
Enables microtubule binding activity. Acts upstream of or within melanosome transport. Located in cell leading edge and microtubule cytoskeleton. Part of protein-containing complex. Is expressed in brain; embryo; and head. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Orthologous to human DCTN1 (dynactin subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 36.9), frontal lobe adult (RPKM 32.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
6 C3; 6 35.94 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83142702..83177103)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83165909..83200118)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700003E16 gene Neighboring gene STARR-positive B cell enhancer ABC_E6447 Neighboring gene WD repeat domain 54 Neighboring gene STARR-seq mESC enhancer starr_16458 Neighboring gene predicted gene 15624 Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 5 Neighboring gene STARR-seq mESC enhancer starr_16459 Neighboring gene STARR-positive B cell enhancer ABC_E4836 Neighboring gene STARR-positive B cell enhancer ABC_E1323 Neighboring gene methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase Neighboring gene STARR-positive B cell enhancer ABC_E6448

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in centriole-centriole cohesion ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within melanosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule anchoring at centrosome ISO
Inferred from Sequence Orthology
more info
 
involved_in motor behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuromuscular process ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear membrane disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of microtubule nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
involved_in ventral spinal cord development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex region ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
part_of centriolar subdistal appendage ISO
Inferred from Sequence Orthology
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of microtubule associated complex ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule plus-end ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of retromer complex ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dynactin subunit 1
Names
150 kDa dynein-associated polypeptide
dynactin 1, retrograde axonal transport

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198866.2NP_001185795.1  dynactin subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_001185795.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an in-frame downstream start codon, compared to variant 1. Variant 2 encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC160400
    Consensus CDS
    CCDS57432.1
    UniProtKB/TrEMBL
    E9Q3M3, Q6NZM3
    Related
    ENSMUSP00000109546.2, ENSMUST00000113913.8
    Conserved Domains (5) summary
    TIGR02168
    Location:203523
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:8891030
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam05109
    Location:84197
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01302
    Location:1277
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:510788
    Dynactin; Dynein associated protein
  2. NM_001198867.2NP_001185796.1  dynactin subunit 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR,lacks multiple exons in the coding region, and uses an in-frame downstream start codon, compared to variant 1. Variant 3 encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 3 and 9 both encode the same isoform (3).
    Source sequence(s)
    AC160400
    Consensus CDS
    CCDS57433.1
    UniProtKB/TrEMBL
    E9Q586, Q3T9V8
    Related
    ENSMUSP00000076623.6, ENSMUST00000077407.12
    Conserved Domains (3) summary
    TIGR02168
    Location:183503
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:1277
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:490768
    Dynactin; Dynein associated protein
  3. NM_001347310.2NP_001334239.1  dynactin subunit 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks multiple exons in the coding region, and uses a novel start codon, compared to variant 1. Variant 4 encodes a protein (isoform 4) with a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC160400
    UniProtKB/TrEMBL
    Q6NZM3
  4. NM_001409578.1NP_001396507.1  dynactin subunit 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC160400
  5. NM_001409579.1NP_001396508.1  dynactin subunit 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC160400
  6. NM_001409580.1NP_001396509.1  dynactin subunit 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC160400
  7. NM_001409581.1NP_001396510.1  dynactin subunit 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC160400
    UniProtKB/TrEMBL
    D3YX34
    Related
    ENSMUSP00000109540.2, ENSMUST00000113907.2
  8. NM_001409582.1NP_001396511.1  dynactin subunit 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC160400
    UniProtKB/TrEMBL
    E9Q586
  9. NM_007835.3NP_031861.2  dynactin subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_031861.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC160400
    Consensus CDS
    CCDS39532.1
    UniProtKB/Swiss-Prot
    E9QLJ1, O08788, Q3TZG7
    UniProtKB/TrEMBL
    Q6NZM3
    Related
    ENSMUSP00000109552.4, ENSMUST00000113919.10
    Conserved Domains (5) summary
    pfam01302
    Location:3094
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:314455
    CASP_C; CASP C terminal
    pfam12455
    Location:525805
    Dynactin; Dynein associated protein
    pfam14915
    Location:227547
    CCDC144C; CCDC144C protein coiled-coil region
    cl23943
    Location:246342
    PCRF; PCRF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83142702..83177103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505493.3XP_006505556.1  dynactin subunit 1 isoform X12

    See identical proteins and their annotated locations for XP_006505556.1

    UniProtKB/TrEMBL
    Q3T9V8
    Conserved Domains (3) summary
    TIGR02168
    Location:183503
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:1277
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:490768
    Dynactin; Dynein associated protein
  2. XM_006505490.3XP_006505553.1  dynactin subunit 1 isoform X8

    UniProtKB/TrEMBL
    Q6NZM3
    Conserved Domains (4) summary
    TIGR02168
    Location:197517
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05109
    Location:64204
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01302
    Location:1277
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:504782
    Dynactin; Dynein associated protein
  3. XM_006505492.3XP_006505555.1  dynactin subunit 1 isoform X10

    UniProtKB/TrEMBL
    Q6NZM3
    Conserved Domains (4) summary
    TIGR02168
    Location:190510
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05109
    Location:64197
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01302
    Location:1277
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:497775
    Dynactin; Dynein associated protein
  4. XM_030255135.2XP_030110995.1  dynactin subunit 1 isoform X4

    UniProtKB/TrEMBL
    E9Q3M3, Q6NZM3
    Conserved Domains (5) summary
    TIGR02168
    Location:203523
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:8891030
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam05109
    Location:84197
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01302
    Location:1277
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:510788
    Dynactin; Dynein associated protein
  5. XM_006505494.2XP_006505557.1  dynactin subunit 1 isoform X12

    See identical proteins and their annotated locations for XP_006505557.1

    UniProtKB/TrEMBL
    Q3T9V8
    Conserved Domains (3) summary
    TIGR02168
    Location:183503
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:1277
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:490768
    Dynactin; Dynein associated protein
  6. XM_036165800.1XP_036021693.1  dynactin subunit 1 isoform X4

    UniProtKB/TrEMBL
    E9Q3M3, Q6NZM3
    Conserved Domains (5) summary
    TIGR02168
    Location:203523
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:8891030
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam05109
    Location:84197
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01302
    Location:1277
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:510788
    Dynactin; Dynein associated protein
  7. XM_006505485.2XP_006505548.1  dynactin subunit 1 isoform X1

    UniProtKB/TrEMBL
    Q6NZM3
    Related
    ENSMUSP00000109551.2, ENSMUST00000113918.8
    Conserved Domains (4) summary
    TIGR02168
    Location:220540
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05109
    Location:101214
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01302
    Location:2994
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:527805
    Dynactin; Dynein associated protein
  8. XM_006505486.4XP_006505549.1  dynactin subunit 1 isoform X2

    UniProtKB/TrEMBL
    Q6NZM3
    Conserved Domains (4) summary
    TIGR02168
    Location:214534
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05109
    Location:81221
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01302
    Location:2994
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:521799
    Dynactin; Dynein associated protein
  9. XM_006505487.3XP_006505550.1  dynactin subunit 1 isoform X3

    UniProtKB/TrEMBL
    Q6NZM3
    Conserved Domains (4) summary
    TIGR02168
    Location:207527
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05109
    Location:81214
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01302
    Location:2994
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:514792
    Dynactin; Dynein associated protein
  10. XM_017321379.2XP_017176868.1  dynactin subunit 1 isoform X5

    UniProtKB/TrEMBL
    Q3T9V8
    Conserved Domains (4) summary
    TIGR02168
    Location:207527
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05109
    Location:81214
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01302
    Location:2994
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:514792
    Dynactin; Dynein associated protein
  11. XM_006505489.3XP_006505552.1  dynactin subunit 1 isoform X6

    UniProtKB/TrEMBL
    Q3T9V8
    Conserved Domains (3) summary
    TIGR02168
    Location:200520
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:2994
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:507785
    Dynactin; Dynein associated protein
  12. XM_006505491.4XP_006505554.1  dynactin subunit 1 isoform X9

    UniProtKB/TrEMBL
    Q3T9V8
    Conserved Domains (3) summary
    TIGR02168
    Location:200520
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam01302
    Location:2994
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:507785
    Dynactin; Dynein associated protein
  13. XM_006505496.5XP_006505559.1  dynactin subunit 1 isoform X15

    UniProtKB/TrEMBL
    Q6NZM3
    Conserved Domains (4) summary
    TIGR02168
    Location:220540
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05109
    Location:101214
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01302
    Location:2994
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:527805
    Dynactin; Dynein associated protein
  14. XM_006505488.3XP_006505551.1  dynactin subunit 1 isoform X4

    See identical proteins and their annotated locations for XP_006505551.1

    UniProtKB/TrEMBL
    E9Q3M3, Q6NZM3
    Conserved Domains (5) summary
    TIGR02168
    Location:203523
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:8891030
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam05109
    Location:84197
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam01302
    Location:1277
    CAP_GLY; CAP-Gly domain
    pfam12455
    Location:510788
    Dynactin; Dynein associated protein