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Dctn1 dynactin 1 [ Mus musculus (house mouse) ]

Gene ID: 13191, updated on 4-Jun-2017
Official Symbol
Dctn1provided by MGI
Official Full Name
dynactin 1provided by MGI
Primary source
MGI:MGI:107745
See related
Ensembl:ENSMUSG00000031865 Vega:OTTMUSG00000024506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p150; Glued; DP-150; DAP-150; AL022633; p150-glued; p150<glued>
Orthologs
Location:
6 C3; 6 35.94 cM
Exon count:
36
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (83165915..83200118)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (83129583..83150112)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700003E16 gene Neighboring gene rhotekin Neighboring gene WD repeat domain 54 Neighboring gene predicted gene 15624 Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 5 Neighboring gene methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase Neighboring gene MOB kinase activator 1A

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
dynein complex binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
centriole-centriole cohesion ISO
Inferred from Sequence Orthology
more info
 
establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
 
melanosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule anchoring at centrosome ISO
Inferred from Sequence Orthology
more info
 
non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope disassembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of microtubule nucleation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
transport along microtubule IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell cortex region ISO
Inferred from Sequence Orthology
more info
 
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centriole ISO
Inferred from Sequence Orthology
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dynactin complex IEA
Inferred from Electronic Annotation
more info
 
dynein complex IEA
Inferred from Electronic Annotation
more info
 
kinetochore ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
microtubule ISO
Inferred from Sequence Orthology
more info
 
microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus-end ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with retromer complex ISO
Inferred from Sequence Orthology
more info
 
spindle ISO
Inferred from Sequence Orthology
more info
 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
dynactin subunit 1
Names
150 kDa dynein-associated polypeptide
dynactin 1, retrograde axonal transport

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198866.1NP_001185795.1  dynactin subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_001185795.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an in-frame downstream start codon, compared to variant 1. Variant 2 encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC066061, BY198890, BY235563
    Consensus CDS
    CCDS57432.1
    UniProtKB/TrEMBL
    E9Q3M3, Q6NZM3
    Related
    ENSMUSP00000109546.1, OTTMUSP00000029380, ENSMUST00000113913.7, OTTMUST00000060250
    Conserved Domains (5) summary
    pfam01302
    Location:1377
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:297438
    CASP_C; CASP C terminal
    pfam12455
    Location:508788
    Dynactin; Dynein associated protein
    pfam14915
    Location:210530
    CCDC144C; CCDC144C protein coiled-coil region
    cl23943
    Location:229325
    PCRF; PCRF domain
  2. NM_001198867.1NP_001185796.1  dynactin subunit 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR,lacks multiple exons in the coding region, and uses an in-frame downstream start codon, compared to variant 1. Variant 3 encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BC066061, BY198890, CF162175
    Consensus CDS
    CCDS57433.1
    UniProtKB/TrEMBL
    E9Q586, Q6NZM3
    Related
    ENSMUSP00000076623.5, OTTMUSP00000029323, ENSMUST00000077407.11, OTTMUST00000060133
    Conserved Domains (5) summary
    pfam01302
    Location:1377
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:277418
    CASP_C; CASP C terminal
    pfam12455
    Location:488768
    Dynactin; Dynein associated protein
    pfam14915
    Location:190510
    CCDC144C; CCDC144C protein coiled-coil region
    cl23943
    Location:209305
    PCRF; PCRF domain
  3. NM_001347310.1NP_001334239.1  dynactin subunit 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks multiple exons in the coding region, and uses a novel start codon, compared to variant 1. Variant 4 encodes a protein (isoform 4) with a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC160400
  4. NM_007835.2NP_031861.2  dynactin subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_031861.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK147769, AK157867, AK162846, CJ210377, U60312
    Consensus CDS
    CCDS39532.1
    UniProtKB/Swiss-Prot
    O08788
    UniProtKB/TrEMBL
    Q3TRF1
    Related
    ENSMUSP00000109552.3, OTTMUSP00000029381, ENSMUST00000113919.9, OTTMUST00000060251
    Conserved Domains (5) summary
    pfam01302
    Location:3094
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:314455
    CASP_C; CASP C terminal
    pfam12455
    Location:525805
    Dynactin; Dynein associated protein
    pfam14915
    Location:227547
    CCDC144C; CCDC144C protein coiled-coil region
    cl23943
    Location:246342
    PCRF; PCRF domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    83165915..83200118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505490.1XP_006505553.1  dynactin subunit 1 isoform X7

    Conserved Domains (5) summary
    pfam01302
    Location:1377
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:291432
    CASP_C; CASP C terminal
    pfam12455
    Location:502782
    Dynactin; Dynein associated protein
    pfam14915
    Location:204524
    CCDC144C; CCDC144C protein coiled-coil region
    cl23943
    Location:223319
    PCRF; PCRF domain
  2. XM_006505492.1XP_006505555.1  dynactin subunit 1 isoform X9

    Conserved Domains (6) summary
    pfam01302
    Location:1377
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:284425
    CASP_C; CASP C terminal
    pfam12455
    Location:495775
    Dynactin; Dynein associated protein
    pfam14915
    Location:197517
    CCDC144C; CCDC144C protein coiled-coil region
    pfam16046
    Location:9221004
    FAM76; FAM76 protein
    cl23943
    Location:216312
    PCRF; PCRF domain
  3. XM_006505493.1XP_006505556.1  dynactin subunit 1 isoform X10

    See identical proteins and their annotated locations for XP_006505556.1

    Conserved Domains (6) summary
    pfam01302
    Location:1377
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:277418
    CASP_C; CASP C terminal
    pfam12455
    Location:488768
    Dynactin; Dynein associated protein
    pfam14915
    Location:190510
    CCDC144C; CCDC144C protein coiled-coil region
    pfam16046
    Location:915997
    FAM76; FAM76 protein
    cl23943
    Location:209305
    PCRF; PCRF domain
  4. XM_006505494.1XP_006505557.1  dynactin subunit 1 isoform X10

    See identical proteins and their annotated locations for XP_006505557.1

    Conserved Domains (6) summary
    pfam01302
    Location:1377
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:277418
    CASP_C; CASP C terminal
    pfam12455
    Location:488768
    Dynactin; Dynein associated protein
    pfam14915
    Location:190510
    CCDC144C; CCDC144C protein coiled-coil region
    pfam16046
    Location:915997
    FAM76; FAM76 protein
    cl23943
    Location:209305
    PCRF; PCRF domain
  5. XM_017321378.1XP_017176867.1  dynactin subunit 1 isoform X4

    UniProtKB/TrEMBL
    E9Q3M3
    Conserved Domains (5) summary
    pfam01302
    Location:1377
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:297438
    CASP_C; CASP C terminal
    pfam12455
    Location:508788
    Dynactin; Dynein associated protein
    pfam14915
    Location:210530
    CCDC144C; CCDC144C protein coiled-coil region
    cl23943
    Location:229325
    PCRF; PCRF domain
  6. XM_006505485.1XP_006505548.1  dynactin subunit 1 isoform X1

    Related
    ENSMUSP00000109551.1, OTTMUSP00000029382, ENSMUST00000113918.7, OTTMUST00000060252
    Conserved Domains (5) summary
    pfam01302
    Location:3094
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:314455
    CASP_C; CASP C terminal
    pfam12455
    Location:525805
    Dynactin; Dynein associated protein
    pfam14915
    Location:227547
    CCDC144C; CCDC144C protein coiled-coil region
    cl23943
    Location:246342
    PCRF; PCRF domain
  7. XM_006505496.3XP_006505559.1  dynactin subunit 1 isoform X12

    Conserved Domains (6) summary
    pfam01302
    Location:3094
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:314455
    CASP_C; CASP C terminal
    pfam12455
    Location:525805
    Dynactin; Dynein associated protein
    pfam14915
    Location:227547
    CCDC144C; CCDC144C protein coiled-coil region
    cl21478
    Location:9451041
    ATP-synt_B; ATP synthase B/B' CF(0)
    cl23943
    Location:246342
    PCRF; PCRF domain
  8. XM_006505486.3XP_006505549.1  dynactin subunit 1 isoform X2

    Conserved Domains (5) summary
    pfam01302
    Location:3094
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:308449
    CASP_C; CASP C terminal
    pfam12455
    Location:519799
    Dynactin; Dynein associated protein
    pfam14915
    Location:221541
    CCDC144C; CCDC144C protein coiled-coil region
    cl23943
    Location:240336
    PCRF; PCRF domain
  9. XM_006505487.2XP_006505550.1  dynactin subunit 1 isoform X3

    Conserved Domains (6) summary
    pfam01302
    Location:3094
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:301442
    CASP_C; CASP C terminal
    pfam12455
    Location:512792
    Dynactin; Dynein associated protein
    pfam14915
    Location:214534
    CCDC144C; CCDC144C protein coiled-coil region
    pfam16046
    Location:9391021
    FAM76; FAM76 protein
    cl23943
    Location:233329
    PCRF; PCRF domain
  10. XM_017321379.1XP_017176868.1  dynactin subunit 1 isoform X5

  11. XM_006505489.2XP_006505552.1  dynactin subunit 1 isoform X6

    Conserved Domains (6) summary
    pfam01302
    Location:3094
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:294435
    CASP_C; CASP C terminal
    pfam12455
    Location:505785
    Dynactin; Dynein associated protein
    pfam14915
    Location:207527
    CCDC144C; CCDC144C protein coiled-coil region
    pfam16046
    Location:9321014
    FAM76; FAM76 protein
    cl23943
    Location:226322
    PCRF; PCRF domain
  12. XM_006505491.3XP_006505554.1  dynactin subunit 1 isoform X8

    Conserved Domains (5) summary
    pfam01302
    Location:3094
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:294435
    CASP_C; CASP C terminal
    pfam12455
    Location:505785
    Dynactin; Dynein associated protein
    pfam14915
    Location:207527
    CCDC144C; CCDC144C protein coiled-coil region
    cl23943
    Location:226322
    PCRF; PCRF domain
  13. XM_006505488.2XP_006505551.1  dynactin subunit 1 isoform X4

    See identical proteins and their annotated locations for XP_006505551.1

    UniProtKB/TrEMBL
    E9Q3M3
    Conserved Domains (5) summary
    pfam01302
    Location:1377
    CAP_GLY; CAP-Gly domain
    pfam08172
    Location:297438
    CASP_C; CASP C terminal
    pfam12455
    Location:508788
    Dynactin; Dynein associated protein
    pfam14915
    Location:210530
    CCDC144C; CCDC144C protein coiled-coil region
    cl23943
    Location:229325
    PCRF; PCRF domain
  14. XM_006505495.3XP_006505558.1  dynactin subunit 1 isoform X11

    UniProtKB/TrEMBL
    D3YX34
    Related
    ENSMUSP00000109540.1, OTTMUSP00000029383, ENSMUST00000113907.1, OTTMUST00000060253
    Conserved Domains (4) summary
    pfam08172
    Location:180321
    CASP_C; CASP C terminal
    pfam12455
    Location:391671
    Dynactin; Dynein associated protein
    pfam14915
    Location:93413
    CCDC144C; CCDC144C protein coiled-coil region
    cl23943
    Location:112208
    PCRF; PCRF domain
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