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NUDT16 nudix hydrolase 16 [ Homo sapiens (human) ]

Gene ID: 131870, updated on 20-Dec-2019

Summary

Official Symbol
NUDT16provided by HGNC
Official Full Name
nudix hydrolase 16provided by HGNC
Primary source
HGNC:HGNC:26442
See related
Ensembl:ENSG00000198585 MIM:617381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in fat (RPKM 14.5), kidney (RPKM 13.4) and 25 other tissues See more
Orthologs

Genomic context

See NUDT16 in Genome Data Viewer
Location:
3q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (131381671..131388830)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (131100515..131107674)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NIMA related kinase 11 Neighboring gene RNA, U6 small nuclear 726, pseudogene Neighboring gene uncharacterized LOC339874 Neighboring gene nudix hydrolase 16 pseudogene 1 Neighboring gene uncharacterized LOC107986025 Neighboring gene uncharacterized LOC105374110

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31265, FLJ34034, FLJ36248

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
ITP binding IDA
Inferred from Direct Assay
more info
PubMed 
XTP binding IDA
Inferred from Direct Assay
more info
PubMed 
chloride ion binding IDA
Inferred from Direct Assay
more info
PubMed 
cobalt ion binding IDA
Inferred from Direct Assay
more info
PubMed 
dITP diphosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
m7G(5')pppN diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
m7G(5')pppN diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
metalloexopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide phosphatase activity, acting on free nucleotides IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide phosphatase activity, acting on free nucleotides IDA
Inferred from Direct Assay
more info
PubMed 
phosphodiesterase decapping endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphodiesterase decapping endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
snoRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
IDP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
RNA phosphodiester bond hydrolysis, endonucleolytic IDA
Inferred from Direct Assay
more info
PubMed 
XDP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
adenosine to inosine editing IMP
Inferred from Mutant Phenotype
more info
PubMed 
dITP catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of rRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleobase-containing small molecule catabolic process TAS
Traceable Author Statement
more info
 
positive regulation of cell cycle process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
snoRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
snoRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
U8 snoRNA-decapping enzyme
Names
IDP phosphatase
IDPase
U8 snoRNA-binding protein H29K
inosine diphosphate phosphatase
m7GpppN-mRNA hydrolase
nucleoside diphosphate-linked moiety X motif 16
nudix (nucleoside diphosphate linked moiety X)-type motif 16
nudix motif 16
testicular tissue protein Li 129
NP_001165376.1
NP_001165377.1
NP_689608.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171905.1NP_001165376.1  U8 snoRNA-decapping enzyme isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC010210, BP199028
    Consensus CDS
    CCDS54641.1
    UniProtKB/Swiss-Prot
    Q96DE0
    Related
    ENSP00000440230.1, ENST00000537561.5
    Conserved Domains (1) summary
    cl00447
    Location:736
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
  2. NM_001171906.1NP_001165377.1  U8 snoRNA-decapping enzyme isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC010210, AK304650, BP219080
    Consensus CDS
    CCDS54640.1
    UniProtKB/Swiss-Prot
    Q96DE0
    Related
    ENSP00000422375.1, ENST00000502852.1
    Conserved Domains (1) summary
    cl00447
    Location:5382
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
  3. NM_152395.3NP_689608.2  U8 snoRNA-decapping enzyme isoform 2

    See identical proteins and their annotated locations for NP_689608.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC010210, CB121755
    Consensus CDS
    CCDS3070.2
    UniProtKB/Swiss-Prot
    Q96DE0
    Related
    ENSP00000429274.1, ENST00000521288.1
    Conserved Domains (1) summary
    pfam00293
    Location:45145
    NUDIX; NUDIX domain

RNA

  1. NR_033268.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010210, AK295852, DC343245

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    131381671..131388830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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