Format

Send to:

Choose Destination

Dbt dihydrolipoamide branched chain transacylase E2 [ Mus musculus (house mouse) ]

Gene ID: 13171, updated on 31-Jan-2019

Summary

Official Symbol
Dbtprovided by MGI
Official Full Name
dihydrolipoamide branched chain transacylase E2provided by MGI
Primary source
MGI:MGI:105386
See related
Ensembl:ENSMUSG00000000340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BCKAD-E2; D3Wsu60e
Expression
Ubiquitous expression in liver E18 (RPKM 14.3), kidney adult (RPKM 13.7) and 27 other tissues See more
Orthologs

Genomic context

See Dbt in Genome Data Viewer
Location:
3 G1; 3 50.37 cM
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (116513075..116549981)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (116215997..116252899)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene CDC14 cell division cycle 14A Neighboring gene predicted gene, 40125 Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) pseudogene Neighboring gene splicing factor, arginine/serine-rich pseudogene Neighboring gene leucine rich repeat containing 39 Neighboring gene tRNA methyltransferase 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity IEA
Inferred from Electronic Annotation
more info
 
lipoic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
Names
branched-chain alpha-keto acid dehydrogenase complex component E2
branched-chain alpha-ketoacid dehydrogenase, E2 subunit
dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex
dihydrolipoyl transacylase
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
part of the BCKAD complex
NP_034152.2
XP_006501039.1
XP_006501040.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357344.1NP_001344273.1  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC025622
    Conserved Domains (1) summary
    cl27351
    Location:2301
    E3_binding; e3 binding domain
  2. NM_010022.4NP_034152.2  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_034152.2

    Status: VALIDATED

    Source sequence(s)
    AC025622
    Consensus CDS
    CCDS17787.1
    UniProtKB/Swiss-Prot
    P53395
    Related
    ENSMUSP00000000349.6, ENSMUST00000000349.10
    Conserved Domains (4) summary
    cd06849
    Location:65138
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    PLN02528
    Location:67482
    PLN02528; 2-oxoisovalerate dehydrogenase E2 component
    pfam00198
    Location:267479
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
    pfam02817
    Location:172205
    E3_binding; e3 binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    116513075..116549981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500976.2XP_006501039.1  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl27351
    Location:2301
    E3_binding; e3 binding domain
  2. XM_006500977.3XP_006501040.1  lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006501040.1

    Conserved Domains (1) summary
    cl27351
    Location:2301
    E3_binding; e3 binding domain
Support Center