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Daxx Fas death domain-associated protein [ Mus musculus (house mouse) ]

Gene ID: 13163, updated on 5-Jan-2023

Summary

Official Symbol
Daxxprovided by MGI
Official Full Name
Fas death domain-associated proteinprovided by MGI
Primary source
MGI:MGI:1197015
See related
Ensembl:ENSMUSG00000002307 AllianceGenome:MGI:1197015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables histone binding activity and transcription coactivator activity. Involved in nucleosome assembly; positive regulation of transcription by RNA polymerase II; and protein localization to chromatin. Acts upstream of or within several processes, including apoptotic signaling pathway; negative regulation of transcription, DNA-templated; and regulation of apoptotic process. Located in PML body and cytosol. Colocalizes with heterochromatin. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in islet cell tumor and ovary epithelial cancer. Orthologous to human DAXX (death domain associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 30.0), thymus adult (RPKM 18.9) and 28 other tissues See more
Orthologs
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Genomic context

See Daxx in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34128379..34134564)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33909404..33915590)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 40 Neighboring gene cDNA sequence BC051226 Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene predicted gene, 19412 Neighboring gene TAP binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150289

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables JUN kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables sumo-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in PML body organization ISO
Inferred from Sequence Orthology
more info
 
involved_in androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to copper ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to diamide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to sodium arsenite ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to unfolded protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with PML body ISO
Inferred from Sequence Orthology
more info
 
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in XY body ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
death domain-associated protein 6
Names
death-domain associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199733.1NP_001186662.1  death domain-associated protein 6

    See identical proteins and their annotated locations for NP_001186662.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK145906, BQ176437, CR974462
    Consensus CDS
    CCDS28633.1
    UniProtKB/Swiss-Prot
    O35613
    UniProtKB/TrEMBL
    Q3UKR0
    Related
    ENSMUSP00000128504.3, ENSMUST00000170075.9
    Conserved Domains (2) summary
    cd13150
    Location:189393
    DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
    pfam03344
    Location:56150
    Daxx; Daxx N-terminal Rassf1C-interacting domain
  2. NM_001355704.1NP_001342633.1  death domain-associated protein 6

    Status: VALIDATED

    Source sequence(s)
    CO041718, CR974462
    Consensus CDS
    CCDS28633.1
    UniProtKB/TrEMBL
    Q3UKR0
    Conserved Domains (2) summary
    cd13150
    Location:189393
    DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
    pfam03344
    Location:56150
    Daxx; Daxx N-terminal Rassf1C-interacting domain
  3. NM_007829.4NP_031855.3  death domain-associated protein 6

    See identical proteins and their annotated locations for NP_031855.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK145906, BQ176437, CR974462
    Consensus CDS
    CCDS28633.1
    UniProtKB/Swiss-Prot
    O35613
    UniProtKB/TrEMBL
    Q3UKR0
    Related
    ENSMUSP00000078390.8, ENSMUST00000079421.15
    Conserved Domains (2) summary
    cd13150
    Location:189393
    DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
    pfam03344
    Location:56150
    Daxx; Daxx N-terminal Rassf1C-interacting domain

RNA

  1. NR_149750.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CO041718, CR974462

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34128379..34134564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523582.4XP_006523645.1  death domain-associated protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006523645.1

    UniProtKB/Swiss-Prot
    O35613
    UniProtKB/TrEMBL
    Q3UKR0
    Conserved Domains (2) summary
    cd13150
    Location:189393
    DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
    pfam03344
    Location:56150
    Daxx; Daxx N-terminal Rassf1C-interacting domain
  2. XM_006523581.4XP_006523644.1  death domain-associated protein 6 isoform X1

    See identical proteins and their annotated locations for XP_006523644.1

    UniProtKB/Swiss-Prot
    O35613
    UniProtKB/TrEMBL
    Q3UKR0
    Conserved Domains (2) summary
    cd13150
    Location:189393
    DAXX_histone_binding; Histone binding domain of the death-domain associated protein (DAXX)
    pfam03344
    Location:56150
    Daxx; Daxx N-terminal Rassf1C-interacting domain