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ZDHHC19 zinc finger DHHC-type palmitoyltransferase 19 [ Homo sapiens (human) ]

Gene ID: 131540, updated on 25-Jan-2022

Summary

Official Symbol
ZDHHC19provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 19provided by HGNC
Primary source
HGNC:HGNC:20713
See related
Ensembl:ENSG00000163958 MIM:618671; AllianceGenome:HGNC:20713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHHC19
Summary
Enables protein-cysteine S-palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in Golgi membrane; endoplasmic reticulum; and perinucleolar compartment. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward testis (RPKM 16.0) See more
Orthologs
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Genomic context

See ZDHHC19 in Genome Data Viewer
Location:
3q29
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (196197443..196211437, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (195924323..195938271, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr3.5812 Neighboring gene uncharacterized LOC105374303 Neighboring gene CRISPRi-validated cis-regulatory element chr3.5817 Neighboring gene uncharacterized LOC105374304 Neighboring gene Sharpr-MPRA regulatory region 7098 Neighboring gene solute carrier family 51 subunit alpha Neighboring gene phosphate cytidylyltransferase 1A, choline

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population.
EBI GWAS Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33345

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinucleolar compartment IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
palmitoyltransferase ZDHHC19
Names
DHHC-19
probable palmitoyltransferase ZDHHC19
zinc finger DHHC domain-containing protein 19
zinc finger DHHC-type containing 19
zinc finger, DHHC domain containing 19
NP_001034706.1
XP_005269336.1
XP_006713556.1
XP_006713557.1
XP_011510719.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039617.2NP_001034706.1  palmitoyltransferase ZDHHC19

    See identical proteins and their annotated locations for NP_001034706.1

    Status: VALIDATED

    Source sequence(s)
    BC022078, BC034801, BG721568, BU929650
    Consensus CDS
    CCDS43190.1
    UniProtKB/Swiss-Prot
    Q8WVZ1
    Related
    ENSP00000296326.3, ENST00000296326.8
    Conserved Domains (1) summary
    pfam01529
    Location:109181
    DHHC; DHHC palmitoyltransferase

RNA

  1. NR_135617.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA724452, AC069257, AK122907, BC022078
    Related
    ENST00000438232.5
  2. NR_135618.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA724452, BC022078
    Related
    ENST00000397544.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    196197443..196211437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713494.2XP_006713557.1  palmitoyltransferase ZDHHC19 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:83155
    DHHC; DHHC palmitoyltransferase
  2. XM_006713493.2XP_006713556.1  palmitoyltransferase ZDHHC19 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:107179
    DHHC; DHHC palmitoyltransferase
  3. XM_011512417.1XP_011510719.1  palmitoyltransferase ZDHHC19 isoform X3

    Conserved Domains (1) summary
    pfam01529
    Location:35107
    DHHC; DHHC palmitoyltransferase
  4. XM_005269279.3XP_005269336.1  palmitoyltransferase ZDHHC19 isoform X4

    Conserved Domains (1) summary
    pfam01529
    Location:109181
    DHHC; DHHC palmitoyltransferase

RNA

  1. XR_246038.2 RNA Sequence

  2. XR_001740013.1 RNA Sequence

  3. XR_001740011.1 RNA Sequence

  4. XR_001740012.1 RNA Sequence

  5. XR_924098.1 RNA Sequence

  6. XR_002959490.1 RNA Sequence

  7. XR_924100.1 RNA Sequence

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