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Dab2 disabled 2, mitogen-responsive phosphoprotein [ Mus musculus (house mouse) ]

Gene ID: 13132, updated on 26-Mar-2024

Summary

Official Symbol
Dab2provided by MGI
Official Full Name
disabled 2, mitogen-responsive phosphoproteinprovided by MGI
Primary source
MGI:MGI:109175
See related
Ensembl:ENSMUSG00000022150 AllianceGenome:MGI:109175
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p96; Doc2; Doc-2; D15Wsu122e; 5730435J12Rik; D630005B22Rik
Summary
Enables several functions, including AP-2 adaptor complex binding activity; clathrin adaptor activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within several processes, including endocytosis; hemopoiesis; and negative regulation of extrinsic apoptotic signaling pathway. Located in apical plasma membrane; cytoplasm; and nucleus. Part of clathrin coat of coated pit. Is expressed in several structures, including central nervous system; egg cylinder; embryo mesenchyme; future hindbrain roof plate; and metanephros. Orthologous to human DAB2 (DAB adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 58.2), placenta adult (RPKM 56.8) and 17 other tissues See more
Orthologs
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Genomic context

See Dab2 in Genome Data Viewer
Location:
15 A1; 15 2.15 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (6329269..6470196)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (6299788..6440715)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37856 Neighboring gene STARR-seq mESC enhancer starr_37857 Neighboring gene STARR-seq mESC enhancer starr_37858 Neighboring gene predicted gene, 41259 Neighboring gene breast cancer metastasis-suppressor 1-like protein pseudogene Neighboring gene predicted gene, 23139 Neighboring gene STARR-seq mESC enhancer starr_37860 Neighboring gene predicted gene 16311 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene complement component 9 Neighboring gene STARR-seq mESC enhancer starr_37861 Neighboring gene FYN binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_37865 Neighboring gene predicted gene 2245 Neighboring gene prohibitin pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AP-2 adaptor complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables cargo receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cargo receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cargo receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables clathrin adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables clathrin adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables clathrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables integrin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in clathrin coat assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leading edge cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in myeloid cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of aldosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of aldosterone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within receptor-mediated endocytosis IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within renal protein absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to steroid hormone ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of clathrin coat of coated pit IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
disabled homolog 2
Names
adaptor molecule disabled-2
differentially expressed in ovarian carcinoma 2
mitogen-responsive phosphoprotein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008702.2NP_001008702.1  disabled homolog 2 isoform b

    See identical proteins and their annotated locations for NP_001008702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC105324, AK162851, AK165519, BB848282
    Consensus CDS
    CCDS37030.1
    UniProtKB/TrEMBL
    Q3TN55, Q3TRE6
    Related
    ENSMUSP00000077166.7, ENSMUST00000078019.13
    Conserved Domains (1) summary
    cd01215
    Location:35171
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  2. NM_001037905.3NP_001032994.1  disabled homolog 2 isoform b

    See identical proteins and their annotated locations for NP_001032994.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 3 both encode isoform b.
    Source sequence(s)
    AC105324, AK162851, AK165519, BB856968, CB952492
    Consensus CDS
    CCDS37030.1
    UniProtKB/TrEMBL
    Q3TN55, Q3TRE6
    Related
    ENSMUSP00000106291.3, ENSMUST00000110663.9
    Conserved Domains (1) summary
    cd01215
    Location:35171
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  3. NM_001102400.1NP_001095870.1  disabled homolog 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC105324, AK162744, BB856968, CB952492
    Consensus CDS
    CCDS49576.1
    UniProtKB/TrEMBL
    E9PX84, Q3TRI2
    Related
    ENSMUSP00000124589.2, ENSMUST00000161812.8
    Conserved Domains (1) summary
    cd01215
    Location:35171
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  4. NM_001310446.1NP_001297375.1  disabled homolog 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal in-frame exon compared to variant 1. The resulting isoform (d) is shorter missing an internal protein segment compared to isoform a.
    Source sequence(s)
    AC105324, AK162744, AK162851, AK165519, AK168375, BB856968, BG072606, CD348957, CD741855
    Consensus CDS
    CCDS79357.1
    UniProtKB/Swiss-Prot
    P98078, Q3U3K1, Q91W56, Q923E1
    UniProtKB/TrEMBL
    E9QL31
    Related
    ENSMUSP00000106292.3, ENSMUST00000110664.9
    Conserved Domains (1) summary
    cd01215
    Location:35171
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  5. NM_023118.5NP_075607.2  disabled homolog 2 isoform a

    See identical proteins and their annotated locations for NP_075607.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC105324, AK162851, AK165519, BB856968, CB598046, CB952492, CD348957
    Consensus CDS
    CCDS37029.1
    UniProtKB/Swiss-Prot
    P98078, Q3U3K1, Q91W56, Q923E1
    UniProtKB/TrEMBL
    A0A0R4J104
    Related
    ENSMUSP00000079689.6, ENSMUST00000080880.12
    Conserved Domains (2) summary
    PHA03247
    Location:288608
    PHA03247; large tegument protein UL36; Provisional
    cd01215
    Location:35171
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    6329269..6470196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245324.1XP_011243626.1  disabled homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_011243626.1

    UniProtKB/Swiss-Prot
    P98078, Q3U3K1, Q91W56, Q923E1
    UniProtKB/TrEMBL
    A0A0R4J104
    Conserved Domains (2) summary
    PHA03247
    Location:288608
    PHA03247; large tegument protein UL36; Provisional
    cd01215
    Location:35171
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  2. XM_030248313.2XP_030104173.1  disabled homolog 2 isoform X3

    UniProtKB/TrEMBL
    E0CXT5, Q9DCE6
    Related
    ENSMUSP00000124478.2, ENSMUST00000161040.8
    Conserved Domains (1) summary
    cd01215
    Location:35171
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  3. XM_017316424.3XP_017171913.1  disabled homolog 2 isoform X1

    UniProtKB/Swiss-Prot
    P98078, Q3U3K1, Q91W56, Q923E1
    UniProtKB/TrEMBL
    A0A0R4J104
    Conserved Domains (2) summary
    PHA03247
    Location:288608
    PHA03247; large tegument protein UL36; Provisional
    cd01215
    Location:35171
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  4. XM_030248312.2XP_030104172.1  disabled homolog 2 isoform X2

    UniProtKB/TrEMBL
    Q3TN55, Q3TRE6
    Conserved Domains (1) summary
    cd01215
    Location:35171
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain