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FAM3D FAM3 metabolism regulating signaling molecule D [ Homo sapiens (human) ]

Gene ID: 131177, updated on 8-Dec-2022

Summary

Official Symbol
FAM3Dprovided by HGNC
Official Full Name
FAM3 metabolism regulating signaling molecule Dprovided by HGNC
Primary source
HGNC:HGNC:18665
See related
Ensembl:ENSG00000198643 MIM:608619; AllianceGenome:HGNC:18665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EF7; OIT1
Summary
Involved in negative regulation of insulin secretion. Predicted to be located in extracellular region. Predicted to be integral component of membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon (RPKM 146.4), salivary gland (RPKM 60.2) and 6 other tissues See more
Orthologs
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Genomic context

See FAM3D in Genome Data Viewer
Location:
3p14.2
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (58633946..58666774, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (58674325..58707192, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (58619673..58652501, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984079 Neighboring gene Sharpr-MPRA regulatory region 12039 Neighboring gene acyl-CoA oxidase 2 Neighboring gene family with sequence similarity 107 member A Neighboring gene FAM3D antisense RNA 1 Neighboring gene uncharacterized LOC105377109 Neighboring gene CFAP20 domain containing Neighboring gene CFAP20DC antisense RNA 1 Neighboring gene CFAP20DC divergent transcript Neighboring gene SNRPB2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein FAM3D
Names
Oncoprotein-induced transcript 1
cytokine-like protein EF-7
family with sequence similarity 3 member D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138805.3NP_620160.1  protein FAM3D precursor

    See identical proteins and their annotated locations for NP_620160.1

    Status: VALIDATED

    Source sequence(s)
    AY358677
    Consensus CDS
    CCDS2893.1
    UniProtKB/Swiss-Prot
    Q547G2, Q96BQ1
    UniProtKB/TrEMBL
    A0A0A8K9B4
    Related
    ENSP00000351632.2, ENST00000358781.7
    Conserved Domains (1) summary
    cd13940
    Location:50220
    ILEI_FAM3C; Interleukin-like EMT inducer

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    58633946..58666774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712967.4XP_006713030.1  protein FAM3D isoform X6

    See identical proteins and their annotated locations for XP_006713030.1

    Conserved Domains (1) summary
    cd13940
    Location:13183
    ILEI_FAM3C; Interleukin-like EMT inducer
  2. XM_011533352.3XP_011531654.1  protein FAM3D isoform X5

    See identical proteins and their annotated locations for XP_011531654.1

    Conserved Domains (1) summary
    cd13940
    Location:14184
    ILEI_FAM3C; Interleukin-like EMT inducer
  3. XM_005264863.5XP_005264920.1  protein FAM3D isoform X4

    See identical proteins and their annotated locations for XP_005264920.1

    Conserved Domains (1) summary
    cd13940
    Location:49219
    ILEI_FAM3C; Interleukin-like EMT inducer
  4. XM_011533350.3XP_011531652.1  protein FAM3D isoform X2

    Conserved Domains (1) summary
    cd13940
    Location:55225
    ILEI_FAM3C; Interleukin-like EMT inducer
  5. XM_011533348.3XP_011531650.1  protein FAM3D isoform X1

    See identical proteins and their annotated locations for XP_011531650.1

    Conserved Domains (1) summary
    cd13940
    Location:56226
    ILEI_FAM3C; Interleukin-like EMT inducer
  6. XM_047447435.1XP_047303391.1  protein FAM3D isoform X6

  7. XM_047447433.1XP_047303389.1  protein FAM3D isoform X5

  8. XM_011533351.3XP_011531653.1  protein FAM3D isoform X3

    See identical proteins and their annotated locations for XP_011531653.1

    UniProtKB/Swiss-Prot
    Q547G2, Q96BQ1
    UniProtKB/TrEMBL
    A0A0A8K9B4
    Conserved Domains (1) summary
    cd13940
    Location:50220
    ILEI_FAM3C; Interleukin-like EMT inducer
  9. XM_047447431.1XP_047303387.1  protein FAM3D isoform X1

  10. XM_047447436.1XP_047303392.1  protein FAM3D isoform X6

  11. XM_047447434.1XP_047303390.1  protein FAM3D isoform X5

  12. XM_006712965.4XP_006713028.1  protein FAM3D isoform X3

    See identical proteins and their annotated locations for XP_006713028.1

    UniProtKB/Swiss-Prot
    Q547G2, Q96BQ1
    UniProtKB/TrEMBL
    A0A0A8K9B4
    Conserved Domains (1) summary
    cd13940
    Location:50220
    ILEI_FAM3C; Interleukin-like EMT inducer
  13. XM_047447432.1XP_047303388.1  protein FAM3D isoform X1

  14. XM_011533354.3XP_011531656.1  protein FAM3D isoform X6

    See identical proteins and their annotated locations for XP_011531656.1

    Conserved Domains (1) summary
    cd13940
    Location:13183
    ILEI_FAM3C; Interleukin-like EMT inducer
  15. XM_011533353.3XP_011531655.1  protein FAM3D isoform X5

    See identical proteins and their annotated locations for XP_011531655.1

    Conserved Domains (1) summary
    cd13940
    Location:14184
    ILEI_FAM3C; Interleukin-like EMT inducer
  16. XM_005264864.5XP_005264921.1  protein FAM3D isoform X4

    See identical proteins and their annotated locations for XP_005264921.1

    Conserved Domains (1) summary
    cd13940
    Location:49219
    ILEI_FAM3C; Interleukin-like EMT inducer
  17. XM_005264862.5XP_005264919.1  protein FAM3D isoform X3

    See identical proteins and their annotated locations for XP_005264919.1

    UniProtKB/Swiss-Prot
    Q547G2, Q96BQ1
    UniProtKB/TrEMBL
    A0A0A8K9B4
    Conserved Domains (1) summary
    cd13940
    Location:50220
    ILEI_FAM3C; Interleukin-like EMT inducer
  18. XM_011533349.4XP_011531651.1  protein FAM3D isoform X1

    See identical proteins and their annotated locations for XP_011531651.1

    Conserved Domains (1) summary
    cd13940
    Location:56226
    ILEI_FAM3C; Interleukin-like EMT inducer

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    58674325..58707192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)