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Ctla2b cytotoxic T lymphocyte-associated protein 2 beta [ Mus musculus (house mouse) ]

Gene ID: 13025, updated on 8-Dec-2022

Summary

Official Symbol
Ctla2bprovided by MGI
Official Full Name
cytotoxic T lymphocyte-associated protein 2 betaprovided by MGI
Primary source
MGI:MGI:88555
See related
Ensembl:ENSMUSG00000074874 AllianceGenome:MGI:88555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ctla-2b
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in several structures, including blood; extraembryonic component; female reproductive system; and lung. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 17.6), liver E18 (RPKM 2.8) and 9 other tissues See more
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Genomic context

See Ctla2b in Genome Data Viewer
Location:
13 B2; 13
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61043165..61045269, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (60895351..60897934, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cathepsin L-like 3 Neighboring gene RIKEN cDNA 4930486L24 gene Neighboring gene trophoblast specific protein beta Neighboring gene cytotoxic T lymphocyte-associated protein 2 alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145801.1NP_001139273.1  protein CTLA-2-beta isoform b

    See identical proteins and their annotated locations for NP_001139273.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK150917, BE448128, DT925153, DT929456
    Consensus CDS
    CCDS49288.1
    UniProtKB/Swiss-Prot
    P12400
    UniProtKB/TrEMBL
    A0A0R4J245
    Related
    ENSMUSP00000131083.2, ENSMUST00000171347.9
    Conserved Domains (1) summary
    smart00848
    Location:1674
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
  2. NM_007797.1NP_031823.1  protein CTLA-2-beta isoform a

    See identical proteins and their annotated locations for NP_031823.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (a).
    Source sequence(s)
    AY034578, BE448128, DT925153
    Consensus CDS
    CCDS49289.1
    UniProtKB/Swiss-Prot
    P12400, Q541S2
    Related
    ENSMUSP00000021884.9, ENSMUST00000021884.10
    Conserved Domains (1) summary
    smart00848
    Location:1674
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    61043165..61045269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244472.2XP_011242774.1  protein CTLA-2-beta isoform X1

    See identical proteins and their annotated locations for XP_011242774.1

    UniProtKB/Swiss-Prot
    P12400, Q541S2
    Conserved Domains (1) summary
    smart00848
    Location:1674
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

RNA

  1. XR_382421.4 RNA Sequence