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Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha [ Mus musculus (house mouse) ]

Gene ID: 13024, updated on 8-Feb-2024

Summary

Official Symbol
Ctla2aprovided by MGI
Official Full Name
cytotoxic T lymphocyte-associated protein 2 alphaprovided by MGI
Primary source
MGI:MGI:88554
See related
Ensembl:ENSMUSG00000044258 AllianceGenome:MGI:88554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ctla-2a
Summary
Predicted to enable cysteine-type endopeptidase activity. Acts upstream of or within negative regulation of inflammatory response; negative regulation of protein processing; and regulation of regulatory T cell differentiation. Located in dendrite. Is expressed in several structures, including blood; cerebral cortex; esophagus; genitourinary system; and lung. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 179.4) and lung adult (RPKM 12.9) See more
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Genomic context

See Ctla2a in Genome Data Viewer
Location:
13 B2; 13 32.56 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (61081969..61084439, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (60934155..60936625, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene cytotoxic T lymphocyte-associated protein 2 beta Neighboring gene trophoblast specific protein beta Neighboring gene trophoblast specific protein alpha Neighboring gene predicted gene, 40976 Neighboring gene predicted gene, 40975

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145799.1NP_001139271.1  protein CTLA-2-alpha isoform b

    See identical proteins and their annotated locations for NP_001139271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AA451288, AK018801, AK132290
    UniProtKB/TrEMBL
    A0A286YDF0
    Conserved Domains (1) summary
    smart00848
    Location:1674
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
  2. NM_007796.2NP_031822.2  protein CTLA-2-alpha isoform a precursor

    See identical proteins and their annotated locations for NP_031822.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK132290, AK167433, BB574774
    Consensus CDS
    CCDS49290.1
    UniProtKB/Swiss-Prot
    P12399, Q91V07
    UniProtKB/TrEMBL
    A0A286YDF0
    Related
    ENSMUSP00000021880.10, ENSMUST00000021880.10
    Conserved Domains (1) summary
    smart00848
    Location:4098
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    61081969..61084439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)