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Cst8 cystatin 8 (cystatin-related epididymal spermatogenic) [ Mus musculus (house mouse) ]

Gene ID: 13012, updated on 1-Mar-2024

Summary

Official Symbol
Cst8provided by MGI
Official Full Name
cystatin 8 (cystatin-related epididymal spermatogenic)provided by MGI
Primary source
MGI:MGI:107161
See related
Ensembl:ENSMUSG00000027442 AllianceGenome:MGI:107161
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cres; Cst-rs1
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of peptidase activity. Located in cell surface; cytoplasm; and extracellular region. Is expressed in epididymis; gonad; and urogenital ridge. Orthologous to human CST8 (cystatin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 110.3) and testis adult (RPKM 50.1) See more
Orthologs
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Genomic context

See Cst8 in Genome Data Viewer
Location:
2 G3; 2 73.56 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (148640759..148647516)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (148798839..148805596)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05977 Neighboring gene cystatin domain containing 1 Neighboring gene cystatin 12 Neighboring gene cystatin 13 Neighboring gene STARR-seq mESC enhancer starr_05978 Neighboring gene cystatin 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cystatin-8
Names
cystatin-related epididymal spermatogenic protein
cystatin-related epididymal-specific protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009978.2NP_034108.1  cystatin-8 precursor

    See identical proteins and their annotated locations for NP_034108.1

    Status: PROVISIONAL

    Source sequence(s)
    AK018943, S49926
    Consensus CDS
    CCDS16848.1
    UniProtKB/Swiss-Prot
    O89102, P32766, Q543A7
    Related
    ENSMUSP00000028931.4, ENSMUST00000028931.10
    Conserved Domains (1) summary
    smart00043
    Location:38140
    CY; Cystatin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    148640759..148647516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498658.5XP_006498721.1  cystatin-8 isoform X1

    See identical proteins and their annotated locations for XP_006498721.1

    UniProtKB/Swiss-Prot
    O89102, P32766, Q543A7
    Conserved Domains (1) summary
    smart00043
    Location:38140
    CY; Cystatin-like domain
  2. XM_006498659.4XP_006498722.1  cystatin-8 isoform X1

    See identical proteins and their annotated locations for XP_006498722.1

    UniProtKB/Swiss-Prot
    O89102, P32766, Q543A7
    Conserved Domains (1) summary
    smart00043
    Location:38140
    CY; Cystatin-like domain