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AADAC arylacetamide deacetylase [ Homo sapiens (human) ]

Gene ID: 13, updated on 11-Sep-2019

Summary

Official Symbol
AADACprovided by HGNC
Official Full Name
arylacetamide deacetylaseprovided by HGNC
Primary source
HGNC:HGNC:17
See related
Ensembl:ENSG00000114771 MIM:600338
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAC; CES5A1
Summary
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 174.6), small intestine (RPKM 100.2) and 4 other tissues See more
Orthologs

Genomic context

See AADAC in Genome Data Viewer
Location:
3q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (151814008..151828488)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (151531769..151546276)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene AADACL2 antisense RNA 1 Neighboring gene arylacetamide deacetylase pseudogene 1 Neighboring gene uncharacterized LOC105374160 Neighboring gene succinate receptor 1 Neighboring gene uncharacterized LOC105374159

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
    Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
catalytic activity TAS
Traceable Author Statement
more info
PubMed 
deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
deacetylase activity TAS
Traceable Author Statement
more info
 
lipase activity TAS
Traceable Author Statement
more info
PubMed 
serine hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
positive regulation of triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of triglyceride catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
arylacetamide deacetylase
Names
arylacetamide deacetylase (esterase)
NP_001077.2
XP_005247161.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086.3NP_001077.2  arylacetamide deacetylase

    See identical proteins and their annotated locations for NP_001077.2

    Status: REVIEWED

    Source sequence(s)
    BC032309, L32179
    Consensus CDS
    CCDS33877.1
    UniProtKB/Swiss-Prot
    P22760
    Related
    ENSP00000232892.6, ENST00000232892.12
    Conserved Domains (2) summary
    COG0657
    Location:33399
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam07859
    Location:107377
    Abhydrolase_3; alpha/beta hydrolase fold

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    151814008..151828488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247104.4XP_005247161.1  arylacetamide deacetylase isoform X1

    Conserved Domains (2) summary
    COG0657
    Location:51382
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam07859
    Location:90360
    Abhydrolase_3; alpha/beta hydrolase fold
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