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AADAC arylacetamide deacetylase [ Homo sapiens (human) ]

Gene ID: 13, updated on 9-Oct-2021

Summary

Official Symbol
AADACprovided by HGNC
Official Full Name
arylacetamide deacetylaseprovided by HGNC
Primary source
HGNC:HGNC:17
See related
Ensembl:ENSG00000114771 MIM:600338
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAC; CES5A1
Summary
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 174.6), small intestine (RPKM 100.2) and 4 other tissues See more
Orthologs
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Genomic context

See AADAC in Genome Data Viewer
Location:
3q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (151814008..151828488)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (151531904..151546276)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene AADACL2 antisense RNA 1 Neighboring gene arylacetamide deacetylase pseudogene 1 Neighboring gene uncharacterized LOC105374160 Neighboring gene succinate receptor 1 Neighboring gene uncharacterized LOC105374159

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables catalytic activity TAS
Traceable Author Statement
more info
PubMed 
enables deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables deacetylase activity TAS
Traceable Author Statement
more info
 
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lipase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables triglyceride lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in positive regulation of triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of triglyceride catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
arylacetamide deacetylase
Names
arylacetamide deacetylase (esterase)
NP_001077.2
XP_005247161.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086.3NP_001077.2  arylacetamide deacetylase

    See identical proteins and their annotated locations for NP_001077.2

    Status: REVIEWED

    Source sequence(s)
    BC032309, L32179
    Consensus CDS
    CCDS33877.1
    UniProtKB/Swiss-Prot
    P22760
    Related
    ENSP00000232892.6, ENST00000232892.12
    Conserved Domains (2) summary
    COG0657
    Location:33399
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam07859
    Location:107377
    Abhydrolase_3; alpha/beta hydrolase fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    151814008..151828488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247104.4XP_005247161.1  arylacetamide deacetylase isoform X1

    Conserved Domains (2) summary
    COG0657
    Location:51382
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam07859
    Location:90360
    Abhydrolase_3; alpha/beta hydrolase fold
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