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AADAC arylacetamide deacetylase [ Homo sapiens (human) ]

Gene ID: 13, updated on 11-Jun-2025
Official Symbol
AADACprovided by HGNC
Official Full Name
arylacetamide deacetylaseprovided by HGNC
Primary source
HGNC:HGNC:17
See related
Ensembl:ENSG00000114771 MIM:600338; AllianceGenome:HGNC:17
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAC; CES5A1
Summary
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 174.6), small intestine (RPKM 100.2) and 4 other tissues See more
Orthologs
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See AADAC in Genome Data Viewer
Location:
3q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (151814116..151828488)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (154563474..154596308)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (151531904..151546276)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene arylacetamide deacetylase like 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:151467502-151468701 Neighboring gene AADACL2 antisense RNA 1 Neighboring gene arylacetamide deacetylase pseudogene 1 Neighboring gene succinate receptor 1 Neighboring gene uncharacterized LOC105374159 Neighboring gene MPRA-validated peak4862 silencer

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity TAS
Traceable Author Statement
more info
PubMed 
enables deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables deacetylase activity TAS
Traceable Author Statement
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables triacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables triacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
 
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of triglyceride catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of triglyceride catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
arylacetamide deacetylase
Names
arylacetamide deacetylase (esterase)
NP_001077.2
XP_005247161.1
XP_054201155.1
XP_054201156.1
XP_054201157.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086.3NP_001077.2  arylacetamide deacetylase

    See identical proteins and their annotated locations for NP_001077.2

    Status: REVIEWED

    Source sequence(s)
    BC032309, L32179
    Consensus CDS
    CCDS33877.1
    UniProtKB/Swiss-Prot
    A8K3L3, D3DNJ6, P22760, Q8N1A9
    Related
    ENSP00000232892.6, ENST00000232892.12
    Conserved Domains (2) summary
    COG0657
    Location:33399
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam07859
    Location:107377
    Abhydrolase_3; alpha/beta hydrolase fold

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    151814116..151828488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247104.5XP_005247161.1  arylacetamide deacetylase isoform X1

    Conserved Domains (2) summary
    COG0657
    Location:51382
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam07859
    Location:90360
    Abhydrolase_3; alpha/beta hydrolase fold

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    154563474..154596308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345181.1XP_054201156.1  arylacetamide deacetylase isoform X2

  2. XM_054345180.1XP_054201155.1  arylacetamide deacetylase isoform X2

  3. XM_054345182.1XP_054201157.1  arylacetamide deacetylase isoform X1