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C2orf73 chromosome 2 open reading frame 73 [ Homo sapiens (human) ]

Gene ID: 129852, updated on 5-Mar-2024

Summary

Official Symbol
C2orf73provided by HGNC
Official Full Name
chromosome 2 open reading frame 73provided by HGNC
Primary source
HGNC:HGNC:26861
See related
Ensembl:ENSG00000177994 AllianceGenome:HGNC:26861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 9.6) See more
Orthologs
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Genomic context

See C2orf73 in Genome Data Viewer
Location:
2p16.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (54330884..54384193)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (54327057..54355776)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (54558021..54588718)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene acylphosphatase 2 Neighboring gene RNA, U7 small nuclear 172 pseudogene Neighboring gene uncharacterized LOC105374610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15758 Neighboring gene TSPY like 6 Neighboring gene uncharacterized LOC102724072 Neighboring gene NANOG hESC enhancer GRCh37_chr2:54711535-54712045 Neighboring gene NANOG hESC enhancer GRCh37_chr2:54724305-54724844 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:54725305-54725489 Neighboring gene C9orf85 pseudogene 1 Neighboring gene spectrin beta, non-erythrocytic 1 Neighboring gene SPTBN1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
uncharacterized protein C2orf73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100396.2NP_001093866.1  uncharacterized protein C2orf73 isoform 1

    See identical proteins and their annotated locations for NP_001093866.1

    Status: VALIDATED

    Source sequence(s)
    AC108929, AK097617, BC031669, BC126246
    Consensus CDS
    CCDS46285.1
    UniProtKB/Swiss-Prot
    A0AV79, A0AV81, Q8N5S3, Q8N7V4
    Related
    ENSP00000381631.2, ENST00000398634.7
    Conserved Domains (1) summary
    pfam15667
    Location:45281
    GDWWSH; Protein of unknown function with motif GDWWSH
  2. NM_001369401.1NP_001356330.1  uncharacterized protein C2orf73 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108929
    UniProtKB/TrEMBL
    B7ZM12, E7ENW1
    Related
    ENSP00000389570.1, ENST00000447328.5
    Conserved Domains (1) summary
    pfam15667
    Location:1224
    GDWWSH; Protein of unknown function with motif GDWWSH
  3. NM_001369403.1NP_001356332.1  uncharacterized protein C2orf73 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108929
    Conserved Domains (1) summary
    pfam15667
    Location:1161
    GDWWSH; Protein of unknown function with motif GDWWSH

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    54330884..54384193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443325.1XP_047299281.1  uncharacterized protein C2orf73 isoform X1

  2. XM_024452687.2XP_024308455.1  uncharacterized protein C2orf73 isoform X1

    Conserved Domains (1) summary
    pfam15667
    Location:103340
    GDWWSH; Protein of unknown function with motif GDWWSH

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    54327057..54355776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340494.1XP_054196469.1  uncharacterized protein C2orf73 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173486.1: Suppressed sequence

    Description
    NM_173486.1: This RefSeq was permanently suppressed because it contains the wrong CDS, and the correct CDS would make it a nonsense-mediated mRNA decay (NMD) candidate.