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Cryge crystallin, gamma E [ Mus musculus (house mouse) ]

Gene ID: 12968, updated on 12-May-2024

Summary

Official Symbol
Crygeprovided by MGI
Official Full Name
crystallin, gamma Eprovided by MGI
Primary source
MGI:MGI:88525
See related
Ensembl:ENSMUSG00000070870 AllianceGenome:MGI:88525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Elo; Cryg-2; Cryg-6; DGcry-2
Summary
Predicted to be a structural constituent of eye lens. Acts upstream of or within lens development in camera-type eye. Is expressed in several structures, including central nervous system; eye; gonad; and gut gland. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 4 multiple types and cataract 7. Orthologous to human CRYGD (crystallin gamma D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 1.7), testis adult (RPKM 0.5) and 3 other tissues See more
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Genomic context

See Cryge in Genome Data Viewer
Location:
1 C2; 1 32.8 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65087716..65090783, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65048555..65051816, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24788 Neighboring gene aldo-keto reductase family 1, member C-like Neighboring gene translation machinery associated 16 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01169 Neighboring gene STARR-seq mESC enhancer starr_01170 Neighboring gene STARR-seq mESC enhancer starr_01171 Neighboring gene STARR-seq mESC enhancer starr_01172 Neighboring gene STARR-seq mESC enhancer starr_01173 Neighboring gene crystallin, gamma D Neighboring gene crystallin, gamma C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC90717

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of eye lens IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lens development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in visual perception ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gamma-crystallin E
Names
eye lens obsolescence
gamma-E-crystallin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420083.1NP_001407012.1  gamma-crystallin E isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158958
  2. NM_007777.4NP_031803.3  gamma-crystallin E isoform 1

    See identical proteins and their annotated locations for NP_031803.3

    Status: VALIDATED

    Source sequence(s)
    AC158958
    Consensus CDS
    CCDS35598.1
    UniProtKB/Swiss-Prot
    O89028, P26999, Q03740, Q9CXK5
    UniProtKB/TrEMBL
    A2RTH4
    Related
    ENSMUSP00000084617.6, ENSMUST00000087359.6
    Conserved Domains (2) summary
    smart00247
    Location:382
    XTALbg; Beta/gamma crystallins
    pfam00030
    Location:89170
    Crystall; Beta/Gamma crystallin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    65087716..65090783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)