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Hapln1 hyaluronan and proteoglycan link protein 1 [ Mus musculus (house mouse) ]

Gene ID: 12950, updated on 5-Sep-2021

Summary

Official Symbol
Hapln1provided by MGI
Official Full Name
hyaluronan and proteoglycan link protein 1provided by MGI
Primary source
MGI:MGI:1337006
See related
Ensembl:ENSMUSG00000021613
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C; LP; CLP; Crt; LP-1; Crtl1; Crtl1l; BB099155
Expression
Biased expression in limb E14.5 (RPKM 38.8), CNS E14 (RPKM 5.4) and 4 other tissues See more
Orthologs
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Genomic context

See Hapln1 in Genome Data Viewer
Location:
13 C3; 13 45.5 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (89688654..89759951)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (89540529..89611832)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (89680241..89751437)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene EGF-like repeats and discoidin I-like domains 3 Neighboring gene predicted gene, 46433 Neighboring gene predicted gene, 34699 Neighboring gene predicted gene, 53805 Neighboring gene acylglycerol kinase pseudogene Neighboring gene high mobility group box 1 pseudogene Neighboring gene versican Neighboring gene predicted gene 4117 Neighboring gene predicted gene, 50611

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent conferring compression resistance RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in skeletal system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in synapse EXP
Inferred from Experiment
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hyaluronan and proteoglycan link protein 1
Names
cartilage link protein 1
cartilage-link protein
cartilage-linking protein 1
link protein
proteoglycan link protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013500.4NP_038528.3  hyaluronan and proteoglycan link protein 1 precursor

    See identical proteins and their annotated locations for NP_038528.3

    Status: VALIDATED

    Source sequence(s)
    AC154460, AK032750
    Consensus CDS
    CCDS26671.1
    UniProtKB/Swiss-Prot
    Q9QUP5
    Related
    ENSMUSP00000022108.8, ENSMUST00000022108.9
    Conserved Domains (4) summary
    cd05877
    Location:55162
    Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP)
    smart00410
    Location:56157
    IG_like; Immunoglobulin like
    cd03518
    Location:161255
    Link_domain_HAPLN_module_1; Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding ...
    cd03519
    Location:262352
    Link_domain_HAPLN_module_2; Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    89688654..89759951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517075.5XP_006517138.1  hyaluronan and proteoglycan link protein 1 isoform X1

    Conserved Domains (3) summary
    cd05877
    Location:54161
    Ig_LP_like; Immunoglobulin (Ig)-like domain of human cartilage link protein (LP)
    cd03518
    Location:160254
    Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
    cd03519
    Location:261351
    Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two ...
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