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Bcar1 breast cancer anti-estrogen resistance 1 [ Mus musculus (house mouse) ]

Gene ID: 12927, updated on 12-May-2024

Summary

Official Symbol
Bcar1provided by MGI
Official Full Name
breast cancer anti-estrogen resistance 1provided by MGI
Primary source
MGI:MGI:108091
See related
Ensembl:ENSMUSG00000031955 AllianceGenome:MGI:108091
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cas; Crkas
Summary
Predicted to enable protein domain specific binding activity and protein kinase binding activity. Involved in G protein-coupled receptor signaling pathway and platelet-derived growth factor receptor signaling pathway. Acts upstream of or within cell migration. Located in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 90.6), small intestine adult (RPKM 67.5) and 25 other tissues See more
Orthologs
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Genomic context

See Bcar1 in Genome Data Viewer
Location:
8 E1; 8 57.98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112437106..112470481, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111710474..111743849, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9323 Neighboring gene STARR-positive B cell enhancer ABC_E885 Neighboring gene STARR-positive B cell enhancer ABC_E5042 Neighboring gene STARR-seq mESC enhancer starr_22707 Neighboring gene STARR-seq mESC enhancer starr_22708 Neighboring gene zinc finger protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10523 Neighboring gene microRNA 7076 Neighboring gene chymotrypsinogen B1 Neighboring gene VISTA enhancer mm1686 Neighboring gene predicted gene, 51589 Neighboring gene STARR-seq mESC enhancer starr_22714 Neighboring gene STARR-seq mESC enhancer starr_22715 Neighboring gene predicted gene, 39252 Neighboring gene craniofacial development protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6685 Neighboring gene STARR-positive B cell enhancer ABC_E6686

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (7)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen receptor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to endothelin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nitric oxide ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotrophin TRK receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
breast cancer anti-estrogen resistance protein 1
Names
CRK-associated substrate
p130 Cas
p130cas
v-crk-associated tyrosine kinase substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198839.1NP_001185768.1  breast cancer anti-estrogen resistance protein 1 isoform A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes isoform A. Isoforms A and B are the same length but differ by 4 N-terminal amino acids.
    Source sequence(s)
    AK167352, BC057578
    Consensus CDS
    CCDS85616.1
    UniProtKB/TrEMBL
    Q3TJB5, Q3TXP6
    Related
    ENSMUSP00000148364.2, ENSMUST00000212349.2
    Conserved Domains (3) summary
    cd11552
    Location:458614
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:471
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
    pfam12026
    Location:659868
    DUF3513; Domain of unknown function (DUF3513)
  2. NM_009954.3NP_034084.2  breast cancer anti-estrogen resistance protein 1 isoform B

    See identical proteins and their annotated locations for NP_034084.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, and encodes isoform B. Isoforms A and B are the same length but differ by 4 N-terminal amino acids.
    Source sequence(s)
    BC057578, BY733553
    Consensus CDS
    CCDS52675.1
    UniProtKB/Swiss-Prot
    Q60869, Q61140, Q6PFF9
    UniProtKB/TrEMBL
    Q3TIT7
    Related
    ENSMUSP00000129584.3, ENSMUST00000166232.4
    Conserved Domains (3) summary
    cd11552
    Location:458614
    Serine_rich_BCAR1; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Breast Cancer Anti-estrogen Resistance 1; a protein interaction module
    cd12001
    Location:571
    SH3_BCAR1; Src homology 3 domain of the CAS (Crk-Associated Substrate) scaffolding protein family member, Breast Cancer Anti-estrogen Resistance 1
    pfam12026
    Location:659868
    DUF3513; Domain of unknown function (DUF3513)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    112437106..112470481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)