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Crh corticotropin releasing hormone [ Mus musculus (house mouse) ]

Gene ID: 12918, updated on 13-Feb-2024

Summary

Official Symbol
Crhprovided by MGI
Official Full Name
corticotropin releasing hormoneprovided by MGI
Primary source
MGI:MGI:88496
See related
Ensembl:ENSMUSG00000049796 AllianceGenome:MGI:88496
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRF; Gm1347
Summary
This gene encodes a member of the corticotropin-releasing factor family and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is a neuropeptide hormone that binds to the corticotropin releasing hormone receptors (CRHR1 and CRHR2) to stimulate the release of adrenocorticotropic hormone from the pituitary gland in response to stress. The encoded protein may also regulate angiogenesis and inflammation. Homozygous knockout mice for this gene exhibit reduced corticosterone levels while the offspring of these mice die perinatally. [provided by RefSeq, Aug 2015]
Expression
Biased expression in frontal lobe adult (RPKM 3.0), cortex adult (RPKM 1.9) and 5 other tissues See more
Orthologs
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Genomic context

See Crh in Genome Data Viewer
Location:
3 A2; 3 5.75 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (19747565..19749560, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (19693401..19695396, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA alanine 14 (anticodon AGC) Neighboring gene STARR-seq mESC enhancer starr_07098 Neighboring gene tripartite motif-containing 55 Neighboring gene predicted gene, 42189 Neighboring gene STARR-seq mESC enhancer starr_07100 Neighboring gene STARR-seq mESC enhancer starr_07101 Neighboring gene predicted gene, 18864 Neighboring gene STARR-seq mESC enhancer starr_07102 Neighboring gene predicted gene 7442

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC151298

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables corticotropin-releasing hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables corticotropin-releasing hormone receptor 1 binding ISO
Inferred from Sequence Orthology
more info
 
enables corticotropin-releasing hormone receptor 2 binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adrenal gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in associative learning ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cocaine ISO
Inferred from Sequence Orthology
more info
 
involved_in female pregnancy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucocorticoid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hormone-mediated apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotory exploration behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epinephrine secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of epinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glucagon secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of glucagon secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of luteinizing hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of corticosterone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of corticotropin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cortisol secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cortisol secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of digestive system process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of NMDA receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of serotonin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in varicosity ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
corticoliberin
Names
corticotropin releasing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205769.3NP_991338.1  corticoliberin preproprotein

    See identical proteins and their annotated locations for NP_991338.1

    Status: REVIEWED

    Source sequence(s)
    BC116921, BE993430, CJ050024
    Consensus CDS
    CCDS17258.1
    UniProtKB/Swiss-Prot
    Q14AA2, Q8CIT0
    Related
    ENSMUSP00000061185.5, ENSMUST00000061294.5
    Conserved Domains (1) summary
    pfam00473
    Location:148185
    CRF; Corticotropin-releasing factor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    19747565..19749560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)