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Cpt2 carnitine palmitoyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 12896, updated on 5-Jul-2025
Official Symbol
Cpt2provided by MGI
Official Full Name
carnitine palmitoyltransferase 2provided by MGI
Primary source
MGI:MGI:109176
See related
Ensembl:ENSMUSG00000028607 AllianceGenome:MGI:109176
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CPTII
Summary
Enables carnitine O-palmitoyltransferase activity. Involved in carnitine shuttle and positive regulation of cold-induced thermogenesis. Acts upstream of or within in utero embryonic development. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease; lipid metabolism disorder; and muscular disease. Orthologous to human CPT2 (carnitine palmitoyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in adrenal adult (RPKM 110.0), duodenum adult (RPKM 94.1) and 22 other tissues See more
Orthologs
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See Cpt2 in Genome Data Viewer
Location:
4 C7; 4 50.18 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (107761179..107780786, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107903982..107923589, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4643 Neighboring gene mago homolog, exon junction complex core component Neighboring gene STARR-positive B cell enhancer ABC_E1649 Neighboring gene CXXC motif containing zinc binding protein Neighboring gene predicted gene, 40221 Neighboring gene RIKEN cDNA 4930407G08 gene

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables carnitine O-octanoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables carnitine O-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables carnitine O-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables carnitine O-palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables carnitine O-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables carnitine O-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carnitine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carnitine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in carnitine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in carnitine shuttle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial matrix IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
carnitine O-palmitoyltransferase 2, mitochondrial
Names
carnitine palmitoyltransferase II
NP_034079.2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009949.3NP_034079.2  carnitine O-palmitoyltransferase 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_034079.2

    Status: VALIDATED

    Source sequence(s)
    AL611936
    Consensus CDS
    CCDS18443.1
    UniProtKB/Swiss-Prot
    P52825, Q3TFS0
    UniProtKB/TrEMBL
    Q3UN55
    Related
    ENSMUSP00000030345.9, ENSMUST00000030345.15
    Conserved Domains (1) summary
    pfam00755
    Location:49648
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    107761179..107780786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)