Cpt2 carnitine palmitoyltransferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cpt2provided by MGI
Official Full Name: carnitine palmitoyltransferase 2provided by MGI
Primary source: MGI:MGI:109176
See related: Ensembl:ENSMUSG00000028607
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CPTII; AI323697
Expression: Broad expression in adrenal adult (RPKM 110.0), duodenum adult (RPKM 94.1) and 22 other tissues See more
Orthologs: human all

Genomic context

Location:: 4 C7; 4 50.18 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	4	NC_000070.6 (107903982..107923589, complement)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	4	NC_000070.5 (107576587..107596194, complement)

Chromosome 4 - NC_000070.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Cpt2 is obligate enzyme in long-chain fatty acid (FA) oxidation; cardiac hypertrophy is linked to impaired FA oxidation. Data (including data from studies using transgenic/knockout mice) suggest that deficiency of Cpt2 in cardiac muscle leads to cardiac hypertrophy/dysfunction with eventual lethality without cardiac fibrosis; mTORC1 is activated in Cpt2(-/-) heart, but inhibition of mTORC1 does not prevent hypertrophy.
Title: Loss of cardiac carnitine palmitoyltransferase 2 results in rapamycin-resistant, acetylation-independent hypertrophy.
Mice acclimatized to thermoneutrality revealed that Cpt2A-null interscapular brown adipose tissue failed to induce the expression of thermogenic genes such as Ucp1 and Pgc1a.
Title: Loss of Adipose Fatty Acid Oxidation Does Not Potentiate Obesity at Thermoneutrality.
Consistent with the known requirement for CPT2 in fatty acid oxidation, macrophages lacking CPT2 were unable to achieve b-oxidation of fatty acids yet still seemed to fully polarize toward an M2 state after stimulation with IL-4 in vitro and in vivo.
Title: Fatty acid oxidation in macrophage polarization.
Cpt2 transcripts decrease following fertilization to undetectable levels and are present again later at the morula stage
Title: Single-cell quantitative RT-PCR analysis of Cpt1b and Cpt2 gene expression in mouse antral oocytes and in preimplantation embryos.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Pathways from BioSystems

Go to the top of the page Help

Fatty Acid Beta Oxidation, organism-specific biosystem (from WikiPathways)
Fatty Acid Beta Oxidation, organism-specific biosystemComplete fatty acid beta-oxidation pathway for saturated and unsaturated fatty acids, developed and curated internally by BiGCaT Bioinformatics. This pathway was previously split into three parts p...
Fatty acid degradation, organism-specific biosystem (from KEGG)
Fatty acid degradation, organism-specific biosystem
Fatty acid degradation
Fatty acid degradation, conserved biosystem (from KEGG)
Fatty acid degradation, conserved biosystem
Fatty acid degradation
Fatty acid metabolism, organism-specific biosystem (from KEGG)
Fatty acid metabolism, organism-specific biosystem
Fatty acid metabolism
Fatty acid metabolism, conserved biosystem (from KEGG)
Fatty acid metabolism, conserved biosystem
Fatty acid metabolism
Fatty acid oxidation, organism-specific biosystem (from WikiPathways)
Fatty acid oxidation, organism-specific biosystem
Fatty acid oxidation
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Import of palmitoyl-CoA into the mitochondrial matrix, organism-specific biosystem (from REACTOME)
Import of palmitoyl-CoA into the mitochondrial matrix, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mitochondrial LC-Fatty Acid Beta-Oxidation, organism-specific biosystem (from WikiPathways)
Mitochondrial LC-Fatty Acid Beta-Oxidation, organism-specific biosystem
Mitochondrial LC-Fatty Acid Beta-Oxidation
PPAR (Peroxisome proliferator-activated receptor) signaling pathway, organism-specific biosystem (from LIPID MAPS)
PPAR (Peroxisome proliferator-activated receptor) signaling pathway, organism-specific biosystem
PPAR (Peroxisome proliferator-activated receptor) signaling pathway
PPAR signaling pathway, organism-specific biosystem (from KEGG)
PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
PPAR signaling pathway, conserved biosystem (from KEGG)
PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
PPAR signaling pathway, organism-specific biosystem (from WikiPathways)
PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH99332 (e-PCR)
- UniSTS:84480

Cpt2 (e-PCR), detects polymorphism
- UniSTS:461891

Cpt2 (e-PCR), detects polymorphism
- UniSTS:461892

U01163 (e-PCR)
- UniSTS:179040

Cpt2 (e-PCR), detects polymorphism
- UniSTS:506816

AI323697 (e-PCR)
- UniSTS:165340

Homology

Homologs of the Cpt2 gene: The Cpt2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, and frog.
Orthologs from Annotation Pipeline: 264 organisms have orthologs with human gene Cpt2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
carnitine O-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
carnitine O-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring acyl groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
lipid metabolic process	IEA Inferred from Electronic Annotation more info
positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
membrane	IEA Inferred from Electronic Annotation more info
mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
mitochondrion	HDA more info	PubMed
mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
mitochondrion	ISO Inferred from Sequence Orthology more info
nucleolus	ISO Inferred from Sequence Orthology more info
nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: carnitine O-palmitoyltransferase 2, mitochondrial

Names: CPT II; carnitine palmitoyltransferase II

NP_034079.2

EC 2.3.1.21

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.