U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SIRPD signal regulatory protein delta [ Homo sapiens (human) ]

Gene ID: 128646, updated on 8-Mar-2025

Summary

Go to the top of the page Help
Official Symbol
SIRPDprovided by HGNC
Official Full Name
signal regulatory protein deltaprovided by HGNC
Primary source
HGNC:HGNC:16248
See related
Ensembl:ENSG00000125900 AllianceGenome:HGNC:16248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPNS1L2; dJ576H24.4
Summary
Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Expression
Restricted expression toward testis (RPKM 26.7) See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SIRPD in Genome Data Viewer
Location:
20p13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (1534251..1557705, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (1583429..1606887, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1514897..1538351, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372499 Neighboring gene uncharacterized LOC105372498 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:1501740-1502939 Neighboring gene RNA, U6 small nuclear 917, pseudogene Neighboring gene uncharacterized LOC107985409 Neighboring gene signal regulatory protein beta 1 Neighboring gene TVP23B pseudogene 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A nomenclature for signal regulatory protein family members. van den Berg TK, et al. J Immunol, 2005 Dec 15. PMID 16339511
  2. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Lee OH, et al. Mol Cell Proteomics, 2011 Feb. PMID 21044950, Free PMC Article
  3. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
signal-regulatory protein delta
Names
SIRP-delta
protein tyrosine phosphatase, non-receptor type substrate 1-like 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410802.1 → NP_001397731.1  signal-regulatory protein delta isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL049634
    Consensus CDS
    CCDS93001.1
    UniProtKB/TrEMBL
    Q5TFQ5
    Related
    ENSP00000371034.1, ENST00000381621.5

  2. NM_178460.3 → NP_848555.2  signal-regulatory protein delta isoform 1 precursor

    See identical proteins and their annotated locations for NP_848555.2

    Status: VALIDATED

    Source sequence(s)
    AL049634, BC033502, DA466740
    Consensus CDS
    CCDS13018.1
    UniProtKB/Swiss-Prot
    B3KS88, Q5TFQ6, Q9H106
    Related
    ENSP00000371036.3, ENST00000381623.4
    Conserved Domains (2) summary
    smart00410
    Location:38 → 118
    IG_like; Immunoglobulin like
    pfam07686
    Location:34 → 140
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    1534251..1557705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439883.1 → XP_047295839.1  signal-regulatory protein delta isoform X1

  2. XM_047439887.1 → XP_047295843.1  signal-regulatory protein delta isoform X4

  3. XM_047439886.1 → XP_047295842.1  signal-regulatory protein delta isoform X3

  4. XM_047439885.1 → XP_047295841.1  signal-regulatory protein delta isoform X2

  5. XM_047439888.1 → XP_047295844.1  signal-regulatory protein delta isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    1583429..1606887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322961.1 → XP_054178936.1  signal-regulatory protein delta isoform X1

  2. XM_054322963.1 → XP_054178938.1  signal-regulatory protein delta isoform X3

  3. XM_054322962.1 → XP_054178937.1  signal-regulatory protein delta isoform X2

  4. XM_054322964.1 → XP_054178939.1  signal-regulatory protein delta isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H106.2 GenPept UniProtKB/Swiss-Prot:Q9H106

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools