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Cox4i1 cytochrome c oxidase subunit 4I1 [ Mus musculus (house mouse) ]

Gene ID: 12857, updated on 5-Feb-2023

Summary

Official Symbol
Cox4i1provided by MGI
Official Full Name
cytochrome c oxidase subunit 4I1provided by MGI
Primary source
MGI:MGI:88473
See related
Ensembl:ENSMUSG00000031818 AllianceGenome:MGI:88473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
COX; Cox4; IV-1; COXIV; Cox4a; COX IV-1
Summary
Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in cytosol and mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 1297.8), kidney adult (RPKM 1026.5) and 28 other tissues See more
Orthologs
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Genomic context

See Cox4i1 in Genome Data Viewer
Location:
8 E1; 8 69.99 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (121394964..121400948)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (120668225..120674209)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1190005I06 gene Neighboring gene predicted gene, 27021 Neighboring gene predicted gene, 33075 Neighboring gene ER membrane protein complex subunit 8 Neighboring gene predicted gene, 39265 Neighboring gene mitochondrial ribosomal protein L30 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mitochondrial respiratory chain complex IV ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Names
cytochrome c oxidase polypeptide IV
cytochrome c oxidase subunit IV
cytochrome c oxidase, subunit IVa
NP_001280488.1
NP_034071.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293559.1NP_001280488.1  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001280488.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK019276, AV469576, BE992841
    Consensus CDS
    CCDS40498.1
    UniProtKB/Swiss-Prot
    P19783, Q545A9
    UniProtKB/TrEMBL
    A0A8C6HCK6, A2RSV8
    Related
    ENSMUSP00000138019.2, ENSMUST00000181586.8
    Conserved Domains (1) summary
    pfam02936
    Location:36168
    COX4; Cytochrome c oxidase subunit IV
  2. NM_009941.3NP_034071.2  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK012583, BE992841, BY250039
    UniProtKB/Swiss-Prot
    P19783
    Conserved Domains (1) summary
    pfam02936
    Location:73205
    COX4; Cytochrome c oxidase subunit IV

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    121394964..121400948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)