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FCRLB Fc receptor like B [ Homo sapiens (human) ]

Gene ID: 127943, updated on 1-Aug-2020

Summary

Official Symbol
FCRLBprovided by HGNC
Official Full Name
Fc receptor like Bprovided by HGNC
Primary source
HGNC:HGNC:26431
See related
Ensembl:ENSG00000162746 MIM:609251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FcRY; FCRL2; FCRLY; FREB2; FCRLM2; FREB-2
Summary
FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in kidney (RPKM 1.2), appendix (RPKM 0.8) and 23 other tissues See more
Orthologs

Genomic context

See FCRLB in Genome Data Viewer
Location:
1q23.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161721544..161728143)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161691598..161697933)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 11 Neighboring gene Fc receptor like A Neighboring gene RNA, 7SL, cytoplasmic 466, pseudogene Neighboring gene dual specificity phosphatase 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • FLJ31052, RP11-474I16.6

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Fc receptor-like B
Names
fc receptor homolog expressed in B cells protein 2
fc receptor-like and mucin-like protein 2
fc receptor-like protein 2
fc receptor-related protein Y

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002901.3NP_001002901.1  Fc receptor-like B isoform 1 precursor

    See identical proteins and their annotated locations for NP_001002901.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as hFCRL2a) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 6 encode the same isoform (1).
    Source sequence(s)
    AL359541, AY670683, BQ014014, DQ021957
    Consensus CDS
    CCDS30927.1
    UniProtKB/Swiss-Prot
    Q6BAA4
    Related
    ENSP00000356925.2, ENST00000367948.6
    Conserved Domains (3) summary
    cd05752
    Location:23100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:104186
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:114190
    IG_like; Immunoglobulin like
  2. NM_001288829.1NP_001275758.1  Fc receptor-like B isoform 2 precursor

    See identical proteins and their annotated locations for NP_001275758.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as hFCRL2c1) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY670684, BQ014014, DQ021957
    Consensus CDS
    CCDS72963.1
    UniProtKB/Swiss-Prot
    Q6BAA4
    Related
    ENSP00000356923.3, ENST00000367946.7
    Conserved Domains (3) summary
    cd05752
    Location:23100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:104186
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:114190
    IG_like; Immunoglobulin like
  3. NM_001288830.1NP_001275759.1  Fc receptor-like B isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as hFCRL2c2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY670685, BQ014014, BX364259, DQ021957
    Consensus CDS
    CCDS72965.1
    UniProtKB/Swiss-Prot
    Q6BAA4
    Related
    ENSP00000356922.1, ENST00000367945.5
    Conserved Domains (3) summary
    cd05752
    Location:1693
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:97179
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:107183
    IG_like; Immunoglobulin like
  4. NM_001288831.1NP_001275760.1  Fc receptor-like B isoform 4 precursor

    See identical proteins and their annotated locations for NP_001275760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4, also known as hFCRL2b1) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY670686, BQ014014, DQ021957
    Consensus CDS
    CCDS72962.1
    UniProtKB/Swiss-Prot
    Q6BAA4
    Related
    ENSP00000338598.5, ENST00000336830.9
    Conserved Domains (3) summary
    cd05752
    Location:23100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:104186
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:114190
    IG_like; Immunoglobulin like
  5. NM_001288832.1NP_001275761.1  Fc receptor-like B isoform 5 precursor

    See identical proteins and their annotated locations for NP_001275761.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5, also known as hFCRL2b2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 5, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY670687, BQ014014, BX364259, DQ021957
    Consensus CDS
    CCDS72964.1
    UniProtKB/Swiss-Prot
    Q6BAA4
    Related
    ENSP00000356921.3, ENST00000367944.3
    Conserved Domains (3) summary
    cd05752
    Location:1693
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:97179
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:107183
    IG_like; Immunoglobulin like
  6. NM_001320241.1NP_001307170.1  Fc receptor-like B isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 6 encode the same isoform (1).
    Source sequence(s)
    AK290733, AY670683, BQ014014
    Consensus CDS
    CCDS30927.1
    UniProtKB/Swiss-Prot
    Q6BAA4
    Conserved Domains (3) summary
    cd05752
    Location:23100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:104186
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:114190
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161721544..161728143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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