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OR2B11 olfactory receptor family 2 subfamily B member 11 [ Homo sapiens (human) ]

Gene ID: 127623, updated on 11-Jun-2021

Summary

Official Symbol
OR2B11provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily B member 11provided by HGNC
Primary source
HGNC:HGNC:31249
See related
Ensembl:ENSG00000177535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR2B11 in Genome Data Viewer
Location:
1q44
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (247449118..247458104, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247612420..247621310, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985375 Neighboring gene NLR family pyrin domain containing 3 Neighboring gene olfactory receptor family 2 subfamily W member 5 pseudogene Neighboring gene germinal center associated signaling and motility like Neighboring gene GCSAML antisense RNA 1 Neighboring gene olfactory receptor family 2 subfamily C member 3

Genomic regions, transcripts, and products

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
GeneReviews: Not available

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactory receptor 2B11
Names
novel 7 transmembrane receptor (rhodopsin family) protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004492.2NP_001004492.1  olfactory receptor 2B11

    See identical proteins and their annotated locations for NP_001004492.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AL606804
    Consensus CDS
    CCDS31090.1
    UniProtKB/Swiss-Prot
    Q5JQS5
    UniProtKB/TrEMBL
    A0A126GVY5
    Related
    ENSP00000492892.1, ENST00000641149.1
    Conserved Domains (2) summary
    pfam00001
    Location:45294
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:39309
    7tm_4; Olfactory receptor

RNA

  1. NR_169840.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606804
    Related
    ENST00000641613.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    247449118..247458104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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