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DCST2 DC-STAMP domain containing 2 [ Homo sapiens (human) ]

Gene ID: 127579, updated on 22-Sep-2022

Summary

Official Symbol
DCST2provided by HGNC
Official Full Name
DC-STAMP domain containing 2provided by HGNC
Primary source
HGNC:HGNC:26562
See related
Ensembl:ENSG00000163354 MIM:619861; AllianceGenome:HGNC:26562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPE42
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in skin (RPKM 28.4), duodenum (RPKM 18.1) and 16 other tissues See more
Orthologs
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Genomic context

See DCST2 in Genome Data Viewer
Location:
1q21.3
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (155018527..155033781, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154157900..154173157, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154991003..155006257, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene lens epithelial protein Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene DC-STAMP domain containing 1 Neighboring gene DCST1 antisense RNA 1 Neighboring gene ADAM metallopeptidase domain 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
A novel common variant in DCST2 is associated with length in early life and height in adulthood.
EBI GWAS Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ32934

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in fusion of sperm to egg plasma membrane involved in single fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sperm-egg recognition ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DC-STAMP domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144622.3NP_653223.2  DC-STAMP domain-containing protein 2

    See identical proteins and their annotated locations for NP_653223.2

    Status: VALIDATED

    Source sequence(s)
    AA401747, BC111794, DB025590
    Consensus CDS
    CCDS1082.2
    UniProtKB/Swiss-Prot
    Q5T1A1, Q96M03
    Related
    ENSP00000357409.3, ENST00000368424.4
    Conserved Domains (2) summary
    pfam07782
    Location:354544
    DC_STAMP; DC-STAMP-like protein
    pfam16031
    Location:720757
    TonB_N; TonB N-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    155018527..155033781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509188.3XP_011507490.1  DC-STAMP domain-containing protein 2 isoform X2

    Conserved Domains (2) summary
    pfam07782
    Location:134324
    DC_STAMP; DC-STAMP-like protein
    pfam16031
    Location:500537
    TonB_N; TonB N-terminal region
  2. XM_047445576.1XP_047301532.1  DC-STAMP domain-containing protein 2 isoform X2

  3. XM_011509189.3XP_011507491.1  DC-STAMP domain-containing protein 2 isoform X3

    Related
    ENST00000368423.5
    Conserved Domains (2) summary
    pfam07782
    Location:22212
    DC_STAMP; DC-STAMP-like protein
    pfam16031
    Location:388425
    TonB_N; TonB N-terminal region
  4. XM_047445571.1XP_047301527.1  DC-STAMP domain-containing protein 2 isoform X1

    Related
    ENSP00000436964.1, ENST00000485982.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    154157900..154173157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)