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Cldn1 claudin 1 [ Mus musculus (house mouse) ]

Gene ID: 12737, updated on 8-Feb-2024

Summary

Official Symbol
Cldn1provided by MGI
Official Full Name
claudin 1provided by MGI
Primary source
MGI:MGI:1276109
See related
Ensembl:ENSMUSG00000022512 AllianceGenome:MGI:1276109
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene die soon after birth as a consequence of dehydration from trandermal water loss, indicating that this gene is indispensable for creating and maintaining the epidermal barrier. The protein encoded by this gene also has gastric tumor suppressive activity, and is a key factor for hepatitis C virus (HCV) entry. [provided by RefSeq, Aug 2010]
Expression
Biased expression in liver E18 (RPKM 82.6), liver adult (RPKM 15.9) and 6 other tissues See more
Orthologs
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Genomic context

See Cldn1 in Genome Data Viewer
Location:
16 B2; 16 18.0 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (26175395..26190589, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (26356645..26371839, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene prolyl 3-hydroxylase 2 Neighboring gene VISTA enhancer mm1097 Neighboring gene expressed sequence AU015336 Neighboring gene STARR-seq mESC enhancer starr_40483 Neighboring gene STARR-seq mESC enhancer starr_40484 Neighboring gene predicted gene, 41436 Neighboring gene STARR-seq mESC enhancer starr_40485 Neighboring gene claudin 16 Neighboring gene STARR-seq mESC enhancer starr_40486 Neighboring gene transmembrane protein 207

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell junction maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of blood-nerve barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial intestinal barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of skin barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation involved in wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interleukin-18 ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic transport across blood-nerve barrier ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction TAS
Traceable Author Statement
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in tight junction ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016674.4NP_057883.1  claudin-1

    See identical proteins and their annotated locations for NP_057883.1

    Status: REVIEWED

    Source sequence(s)
    AK036780, CK626537
    Consensus CDS
    CCDS28087.1
    UniProtKB/Swiss-Prot
    O88551
    UniProtKB/TrEMBL
    A7UKX1, Q4FJV3
    Related
    ENSMUSP00000023154.3, ENSMUST00000023154.3
    Conserved Domains (1) summary
    pfam00822
    Location:5182
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    26175395..26190589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)