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ASB17 ankyrin repeat and SOCS box containing 17 [ Homo sapiens (human) ]

Gene ID: 127247, updated on 25-Nov-2025
Official Symbol
ASB17provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 17provided by HGNC
Primary source
HGNC:HGNC:19769
See related
Ensembl:ENSG00000154007 MIM:619936; AllianceGenome:HGNC:19769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Asb-17
Summary
Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Restricted expression toward testis (RPKM 21.2) See more
Orthologs
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See ASB17 in Genome Data Viewer
Location:
1p31.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (75918873..75932404, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (75756850..75775621, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (76384558..76398089, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Rab geranylgeranyltransferase subunit beta Neighboring gene small nucleolar RNA, C/D box 45B Neighboring gene mutS homolog 4 Neighboring gene uncharacterized LOC105378806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1209 Neighboring gene uncharacterized LOC101927342

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Expression of testis specific ankyrin repeat and SOCS box-containing 17 gene. Guo JH, et al. Arch Androl, 2004 May-Jun. PMID 15204681
  2. ASB17 Facilitates the Burst of LPS-Induced Inflammation Through Maintaining TRAF6 Stability. Wan P, et al. Front Cell Infect Microbiol, 2022. PMID 35174103, Free PMC Article
  3. BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress. Chen FY, et al. J Cell Biol, 2019 Sep 2. PMID 31387940, Free PMC Article
  4. ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. Kohroki J, et al. FEBS Lett, 2005 Dec 19. PMID 16325183
  5. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ASB17 Facilitates the Burst of LPS-Induced Inflammation Through Maintaining TRAF6 Stability.
    Title: ASB17 Facilitates the Burst of LPS-Induced Inflammation Through Maintaining TRAF6 Stability.
  2. expressed exclusively in testis
    Title: Expression of testis specific ankyrin repeat and SOCS box-containing 17 gene.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in apical ectoplasmic specialization IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
Preferred Names
ankyrin repeat and SOCS box protein 17

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080868.3 → NP_543144.1  ankyrin repeat and SOCS box protein 17

    See identical proteins and their annotated locations for NP_543144.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and is thought to encode the functional protein.
    Source sequence(s)
    BC036573
    Consensus CDS
    CCDS671.1
    UniProtKB/Swiss-Prot
    B1APB8, Q8N0X5, Q8WXJ9
    Related
    ENSP00000284142.6, ENST00000284142.7
    Conserved Domains (2) summary
    cd03716
    Location:251 → 294
    SOCS_ASB_like; SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable ...
    cl02529
    Location:95 → 177
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

RNA

  1. NR_026546.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK098606, BC022517

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    75918873..75932404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445206.1 → XP_047301162.1  ankyrin repeat and SOCS box protein 17 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    75756850..75775621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334314.1 → XP_054190289.1  ankyrin repeat and SOCS box protein 17 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WXJ9.2 GenPept UniProtKB/Swiss-Prot:Q8WXJ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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