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ASB17 ankyrin repeat and SOCS box containing 17 [ Homo sapiens (human) ]

Gene ID: 127247, updated on 5-Aug-2022

Summary

Official Symbol
ASB17provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 17provided by HGNC
Primary source
HGNC:HGNC:19769
See related
Ensembl:ENSG00000154007 MIM:619936; AllianceGenome:HGNC:19769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Asb-17
Summary
Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 21.2) See more
Orthologs
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Genomic context

See ASB17 in Genome Data Viewer
Location:
1p31.1
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (75918873..75932404, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (75756850..75770387, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (76384558..76398089, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Rab geranylgeranyltransferase subunit beta Neighboring gene small nucleolar RNA, C/D box 45B Neighboring gene mutS homolog 4 Neighboring gene uncharacterized LOC105378806 Neighboring gene uncharacterized LOC101927342

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080868.3NP_543144.1  ankyrin repeat and SOCS box protein 17

    See identical proteins and their annotated locations for NP_543144.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and is thought to encode the functional protein.
    Source sequence(s)
    BC036573
    Consensus CDS
    CCDS671.1
    UniProtKB/Swiss-Prot
    Q8N0X5, Q8WXJ9
    Related
    ENSP00000284142.6, ENST00000284142.7
    Conserved Domains (2) summary
    cd03716
    Location:251294
    SOCS_ASB_like; SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable ...
    cl02529
    Location:95177
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

RNA

  1. NR_026546.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK098606, BC022517

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    75918873..75932404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445206.1XP_047301162.1  ankyrin repeat and SOCS box protein 17 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    75756850..75770387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)