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Cirbp cold inducible RNA binding protein [ Mus musculus (house mouse) ]

Gene ID: 12696, updated on 26-Sep-2022

Summary

Official Symbol
Cirbpprovided by MGI
Official Full Name
cold inducible RNA binding proteinprovided by MGI
Primary source
MGI:MGI:893588
See related
Ensembl:ENSMUSG00000045193 AllianceGenome:MGI:893588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cirp
Summary
Enables poly(U) RNA binding activity and translation repressor activity. Involved in stress granule assembly. Acts upstream of or within cellular response to cold; negative regulation of cell growth; and regulation of cell cycle G1/S phase transition. Located in cytoplasmic stress granule and nucleoplasm. Is expressed in several structures, including brain and retina. Orthologous to human CIRBP (cold inducible RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 77.5), whole brain E14.5 (RPKM 68.5) and 28 other tissues See more
Orthologs
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Genomic context

See Cirbp in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80001824..80008620)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80165990..80172786)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta subunit associated regulatory protein Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit Neighboring gene midnolin Neighboring gene family with sequence similarity 174, member C Neighboring gene ephrin A2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables small ribosomal subunit rRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables translation repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cold-inducible RNA-binding protein
Names
A18 hnRNP
glycine-rich RNA-binding protein CIRP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379421.1NP_001366350.1  cold-inducible RNA-binding protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159999
    Conserved Domains (1) summary
    cd12449
    Location:685
    RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
  2. NM_001379422.1NP_001366351.1  cold-inducible RNA-binding protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159999
    UniProtKB/Swiss-Prot
    Q61413
    UniProtKB/TrEMBL
    A0A6P5QN30
    Conserved Domains (1) summary
    cd12449
    Location:685
    RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
  3. NM_001379423.1NP_001366352.1  cold-inducible RNA-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159999
    Conserved Domains (1) summary
    cd12449
    Location:685
    RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
  4. NM_001379424.1NP_001366353.1  cold-inducible RNA-binding protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159999
    UniProtKB/Swiss-Prot
    Q61413
    UniProtKB/TrEMBL
    A0A6P5QN30
    Conserved Domains (1) summary
    cd12449
    Location:685
    RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
  5. NM_001379425.1NP_001366354.1  cold-inducible RNA-binding protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC159999
    UniProtKB/Swiss-Prot
    Q61413
    UniProtKB/TrEMBL
    A0A6P5QN30
    Conserved Domains (1) summary
    cd12449
    Location:685
    RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
  6. NM_007705.3NP_031731.1  cold-inducible RNA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_031731.1

    Status: VALIDATED

    Source sequence(s)
    AI841072, AK132584
    Consensus CDS
    CCDS35975.1
    UniProtKB/Swiss-Prot
    P60824, Q61413
    UniProtKB/TrEMBL
    A0A6P5QN30
    Related
    ENSMUSP00000101004.3, ENSMUST00000105365.9
    Conserved Domains (1) summary
    cd12449
    Location:685
    RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

RNA

  1. NR_152857.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159999, BC075699, BE985260, BQ445205, CJ046415
    Related
    ENSMUST00000054666.7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80001824..80008620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)