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AADACL3 arylacetamide deacetylase like 3 [ Homo sapiens (human) ]

Gene ID: 126767, updated on 5-Jan-2022

Summary

Official Symbol
AADACL3provided by HGNC
Official Full Name
arylacetamide deacetylase like 3provided by HGNC
Primary source
HGNC:HGNC:32037
See related
Ensembl:ENSG00000188984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable hydrolase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in placenta (RPKM 1.1), skin (RPKM 0.7) and 1 other tissue See more
Orthologs
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Genomic context

See AADACL3 in Genome Data Viewer
Location:
1p36.21
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (12716110..12728760)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12776113..12788727)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene dehydrogenase/reductase 3 Neighboring gene Sharpr-MPRA regulatory region 11784 Neighboring gene arylacetamide deacetylase like 4 Neighboring gene cilia and flagella associated protein 107 Neighboring gene PRAME family member 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
arylacetamide deacetylase-like 3
NP_001096640.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103170.3NP_001096640.2  arylacetamide deacetylase-like 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC244670, AK127828, BG697255
    Consensus CDS
    CCDS41253.2
    UniProtKB/Swiss-Prot
    Q5VUY0
    Related
    ENSP00000352268.6, ENST00000359318.8
    Conserved Domains (1) summary
    pfam07859
    Location:115378
    Abhydrolase_3; alpha/beta hydrolase fold

RNA

  1. NR_111984.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC244670, AK127828, BG697255
    Related
    ENST00000620146.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    12716110..12728760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001103169.1: Suppressed sequence

    Description
    NM_001103169.1: This RefSeq was permanently suppressed because currently there is insufficient support for the protein.
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