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TDRD10 tudor domain containing 10 [ Homo sapiens (human) ]

Gene ID: 126668, updated on 5-Jan-2022

Summary

Official Symbol
TDRD10provided by HGNC
Official Full Name
tudor domain containing 10provided by HGNC
Primary source
HGNC:HGNC:25316
See related
Ensembl:ENSG00000163239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable RNA binding activity. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis (RPKM 14.5), lung (RPKM 1.6) and 2 other tissues See more
Orthologs
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Genomic context

See TDRD10 in Genome Data Viewer
Location:
1q21.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (154502219..154548147)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154474695..154520623)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene IL6R antisense RNA 1 Neighboring gene interleukin 6 receptor Neighboring gene proteasome 26S subunit, non-ATPase, 8 pseudogene 1 Neighboring gene Src homology 2 domain containing E Neighboring gene Sharpr-MPRA regulatory region 5559 Neighboring gene UBE2Q1 antisense RNA 1 Neighboring gene ubiquitin conjugating enzyme E2 Q1 Neighboring gene uncharacterized LOC107985206

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434M202

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in P granule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in piRNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tudor domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098475.2NP_001091945.1  tudor domain-containing protein 10 isoform a

    See identical proteins and their annotated locations for NP_001091945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL162591, AL592078
    Consensus CDS
    CCDS41406.1
    UniProtKB/Swiss-Prot
    Q5VZ19
    Related
    ENSP00000357465.3, ENST00000368480.3
    Conserved Domains (3) summary
    COG0724
    Location:8103
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00590
    Location:36103
    RRM_SF; RNA recognition motif (RRM) superfamily
    pfam00567
    Location:219315
    TUDOR; Tudor domain
  2. NM_182499.4NP_872305.3  tudor domain-containing protein 10 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform b which has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL162591, AL592078
    Consensus CDS
    CCDS30878.2
    UniProtKB/Swiss-Prot
    Q5VZ19
    Related
    ENSP00000357467.4, ENST00000368482.8
    Conserved Domains (3) summary
    COG0724
    Location:8103
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00590
    Location:36103
    RRM_SF; RNA recognition motif (RRM) superfamily
    pfam00567
    Location:219315
    TUDOR; Tudor domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    154502219..154548147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509152.2XP_011507454.1  tudor domain-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_011507454.1

    Conserved Domains (3) summary
    COG0724
    Location:7135
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam00567
    Location:251347
    TUDOR; Tudor domain
    cl17169
    Location:77134
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_011509153.2XP_011507455.1  tudor domain-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_011507455.1

    Conserved Domains (3) summary
    COG0724
    Location:7135
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam00567
    Location:251347
    TUDOR; Tudor domain
    cl17169
    Location:77134
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_011509155.2XP_011507457.1  tudor domain-containing protein 10 isoform X3

    Conserved Domains (3) summary
    COG0724
    Location:7135
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam00567
    Location:251347
    TUDOR; Tudor domain
    cl17169
    Location:77134
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_011509156.2XP_011507458.1  tudor domain-containing protein 10 isoform X4

    Conserved Domains (3) summary
    COG0724
    Location:7110
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00590
    Location:43110
    RRM_SF; RNA recognition motif (RRM) superfamily
    pfam00567
    Location:226322
    TUDOR; Tudor domain
  5. XM_011509157.2XP_011507459.1  tudor domain-containing protein 10 isoform X5

    Conserved Domains (3) summary
    COG0724
    Location:7110
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00590
    Location:43110
    RRM_SF; RNA recognition motif (RRM) superfamily
    pfam00567
    Location:226322
    TUDOR; Tudor domain
  6. XM_011509154.2XP_011507456.1  tudor domain-containing protein 10 isoform X2

    Conserved Domains (3) summary
    COG0724
    Location:8128
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam00567
    Location:244340
    TUDOR; Tudor domain
    cl17169
    Location:70127
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. XM_011509162.3XP_011507464.1  tudor domain-containing protein 10 isoform X10

    Conserved Domains (2) summary
    COG0724
    Location:7135
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:77134
    RRM_SF; RNA recognition motif (RRM) superfamily
  8. XM_011509159.3XP_011507461.1  tudor domain-containing protein 10 isoform X7

    Conserved Domains (1) summary
    pfam00567
    Location:170266
    TUDOR; Tudor domain
  9. XM_011509158.2XP_011507460.1  tudor domain-containing protein 10 isoform X6

    Conserved Domains (1) summary
    pfam00567
    Location:181277
    TUDOR; Tudor domain
  10. XM_024453047.1XP_024308815.1  tudor domain-containing protein 10 isoform X6

    Conserved Domains (1) summary
    pfam00567
    Location:181277
    TUDOR; Tudor domain
  11. XM_011509161.1XP_011507463.1  tudor domain-containing protein 10 isoform X9

    See identical proteins and their annotated locations for XP_011507463.1

    UniProtKB/Swiss-Prot
    Q5VZ19
    Conserved Domains (1) summary
    pfam00567
    Location:53149
    TUDOR; Tudor domain
  12. XM_017000255.1XP_016855744.1  tudor domain-containing protein 10 isoform X8

  13. XM_011509160.2XP_011507462.1  tudor domain-containing protein 10 isoform X9

    See identical proteins and their annotated locations for XP_011507462.1

    UniProtKB/Swiss-Prot
    Q5VZ19
    Conserved Domains (1) summary
    pfam00567
    Location:53149
    TUDOR; Tudor domain
  14. XM_006711156.2XP_006711219.1  tudor domain-containing protein 10 isoform X9

    See identical proteins and their annotated locations for XP_006711219.1

    UniProtKB/Swiss-Prot
    Q5VZ19
    Conserved Domains (1) summary
    pfam00567
    Location:53149
    TUDOR; Tudor domain
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