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TDRD10 tudor domain containing 10 [ Homo sapiens (human) ]

Gene ID: 126668, updated on 5-Mar-2024

Summary

Official Symbol
TDRD10provided by HGNC
Official Full Name
tudor domain containing 10provided by HGNC
Primary source
HGNC:HGNC:25316
See related
Ensembl:ENSG00000163239 AllianceGenome:HGNC:25316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 14.5), lung (RPKM 1.6) and 2 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See TDRD10 in Genome Data Viewer
Location:
1q21.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (154502219..154548147)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (153639357..153685274)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154474695..154520623)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1357 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154378343-154378949 Neighboring gene IL6R antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154390689-154391202 Neighboring gene interleukin 6 receptor Neighboring gene proteasome 26S subunit, non-ATPase, 8 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154399170-154399670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154399671-154400171 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154404493-154405326 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154405327-154406158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154406159-154406992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154417761-154418260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154437441-154437942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154461067-154461569 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:154461570-154462071 Neighboring gene Src homology 2 domain containing E Neighboring gene Sharpr-MPRA regulatory region 5559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1779 Neighboring gene UBE2Q1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1359 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154530992-154531573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:154531574-154532154 Neighboring gene ubiquitin conjugating enzyme E2 Q1 Neighboring gene uncharacterized LOC107985206

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp434M202

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tudor domain-containing protein 10

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098475.2NP_001091945.1  tudor domain-containing protein 10 isoform a

    See identical proteins and their annotated locations for NP_001091945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL162591, AL592078
    Consensus CDS
    CCDS41406.1
    UniProtKB/Swiss-Prot
    A4FU09, B0QZ53, B4DXV4, Q3ZCP1, Q3ZCS7, Q5SXY7, Q5VZ19, Q6UXV2, Q8TCN3
    Related
    ENSP00000357465.3, ENST00000368480.3
    Conserved Domains (3) summary
    COG0724
    Location:8103
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00590
    Location:36103
    RRM_SF; RNA recognition motif (RRM) superfamily
    pfam00567
    Location:219315
    TUDOR; Tudor domain
  2. NM_182499.4NP_872305.3  tudor domain-containing protein 10 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform b which has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL162591, AL592078
    Consensus CDS
    CCDS30878.2
    UniProtKB/Swiss-Prot
    Q5VZ19
    Related
    ENSP00000357467.4, ENST00000368482.8
    Conserved Domains (3) summary
    COG0724
    Location:8103
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00590
    Location:36103
    RRM_SF; RNA recognition motif (RRM) superfamily
    pfam00567
    Location:219315
    TUDOR; Tudor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    154502219..154548147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509152.3XP_011507454.1  tudor domain-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_011507454.1

    Conserved Domains (3) summary
    COG0724
    Location:7135
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam00567
    Location:251347
    TUDOR; Tudor domain
    cl17169
    Location:77134
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_011509153.3XP_011507455.1  tudor domain-containing protein 10 isoform X1

    See identical proteins and their annotated locations for XP_011507455.1

    Conserved Domains (3) summary
    COG0724
    Location:7135
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam00567
    Location:251347
    TUDOR; Tudor domain
    cl17169
    Location:77134
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_011509155.3XP_011507457.1  tudor domain-containing protein 10 isoform X3

    Conserved Domains (3) summary
    COG0724
    Location:7135
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam00567
    Location:251347
    TUDOR; Tudor domain
    cl17169
    Location:77134
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_011509156.3XP_011507458.1  tudor domain-containing protein 10 isoform X4

    Conserved Domains (3) summary
    COG0724
    Location:7110
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00590
    Location:43110
    RRM_SF; RNA recognition motif (RRM) superfamily
    pfam00567
    Location:226322
    TUDOR; Tudor domain
  5. XM_011509157.3XP_011507459.1  tudor domain-containing protein 10 isoform X5

    Conserved Domains (3) summary
    COG0724
    Location:7110
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00590
    Location:43110
    RRM_SF; RNA recognition motif (RRM) superfamily
    pfam00567
    Location:226322
    TUDOR; Tudor domain
  6. XM_011509154.3XP_011507456.1  tudor domain-containing protein 10 isoform X2

    Conserved Domains (3) summary
    COG0724
    Location:8128
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam00567
    Location:244340
    TUDOR; Tudor domain
    cl17169
    Location:70127
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. XM_047444646.1XP_047300602.1  tudor domain-containing protein 10 isoform X11

  8. XM_011509159.4XP_011507461.1  tudor domain-containing protein 10 isoform X7

    Conserved Domains (1) summary
    pfam00567
    Location:170266
    TUDOR; Tudor domain
  9. XM_011509158.2XP_011507460.1  tudor domain-containing protein 10 isoform X6

    Conserved Domains (1) summary
    pfam00567
    Location:181277
    TUDOR; Tudor domain
  10. XM_011509161.1XP_011507463.1  tudor domain-containing protein 10 isoform X9

    See identical proteins and their annotated locations for XP_011507463.1

    UniProtKB/Swiss-Prot
    Q5VZ19
    Conserved Domains (1) summary
    pfam00567
    Location:53149
    TUDOR; Tudor domain
  11. XM_047444641.1XP_047300597.1  tudor domain-containing protein 10 isoform X10

  12. XM_017000255.1XP_016855744.1  tudor domain-containing protein 10 isoform X8

  13. XM_011509160.2XP_011507462.1  tudor domain-containing protein 10 isoform X9

    See identical proteins and their annotated locations for XP_011507462.1

    UniProtKB/Swiss-Prot
    Q5VZ19
    Conserved Domains (1) summary
    pfam00567
    Location:53149
    TUDOR; Tudor domain

RNA

  1. XR_007076385.1 RNA Sequence

  2. XR_007076384.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    153639357..153685274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334231.1XP_054190206.1  tudor domain-containing protein 10 isoform X1

  2. XM_054334232.1XP_054190207.1  tudor domain-containing protein 10 isoform X1

  3. XM_054334234.1XP_054190209.1  tudor domain-containing protein 10 isoform X3

  4. XM_054334235.1XP_054190210.1  tudor domain-containing protein 10 isoform X4

  5. XM_054334236.1XP_054190211.1  tudor domain-containing protein 10 isoform X5

  6. XM_054334233.1XP_054190208.1  tudor domain-containing protein 10 isoform X2

  7. XM_054334243.1XP_054190218.1  tudor domain-containing protein 10 isoform X12

  8. XM_054334238.1XP_054190213.1  tudor domain-containing protein 10 isoform X7

  9. XM_054334237.1XP_054190212.1  tudor domain-containing protein 10 isoform X6

  10. XM_054334242.1XP_054190217.1  tudor domain-containing protein 10 isoform X9

  11. XM_054334244.1XP_054190219.1  tudor domain-containing protein 10 isoform X10

  12. XM_054334239.1XP_054190214.1  tudor domain-containing protein 10 isoform X8

  13. XM_054334241.1XP_054190216.1  tudor domain-containing protein 10 isoform X9

  14. XM_054334240.1XP_054190215.1  tudor domain-containing protein 10 isoform X9