U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chek1 checkpoint kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 12649, updated on 6-Jun-2024

Summary

Official Symbol
Chek1provided by MGI
Official Full Name
checkpoint kinase 1provided by MGI
Primary source
MGI:MGI:1202065
See related
Ensembl:ENSMUSG00000032113 AllianceGenome:MGI:1202065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chk1; rad27
Summary
Enables histone kinase activity (H3-T11 specific). Involved in epigenetic maintenance of chromatin in transcription-competent conformation; regulation of histone H3-K9 acetylation; and regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage. Acts upstream of or within several processes, including DNA damage checkpoint signaling; G2/M transition of mitotic cell cycle; and inner cell mass cell proliferation. Located in chromatin; nucleus; and replication fork. Is expressed in several structures, including adrenal medulla; early conceptus; gonad; gut; and trunk mesenchyme derived from neural crest. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 8.0), liver E14 (RPKM 5.6) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Chek1 in Genome Data Viewer
Location:
9 A4; 9 20.67 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (36619935..36637897, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (36708482..36726658, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700027I24 gene Neighboring gene acrosomal vesicle protein 1 Neighboring gene STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E709 Neighboring gene predicted gene, 26787 Neighboring gene etoposide induced 2.4 mRNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (7)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H3T11 kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3T11 kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage checkpoint signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process involved in development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within inner cell mass cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2/M transition checkpoint ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitotic cell cycle checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nucleus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of mitotic centrosome separation ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in replication fork IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase Chk1
Names
CHK1 checkpoint homolog
checkpoint kinase 1 homolog
rad27 homolog
NP_001397134.1
NP_001397135.1
NP_001397136.1
NP_031717.2
XP_017168606.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410205.1NP_001397134.1  serine/threonine-protein kinase Chk1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155921
  2. NM_001410206.1NP_001397135.1  serine/threonine-protein kinase Chk1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC155921
  3. NM_001410207.1NP_001397136.1  serine/threonine-protein kinase Chk1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC155921
    UniProtKB/Swiss-Prot
    O35280, O54925, Q8CI40, Q9D0N2
    UniProtKB/TrEMBL
    Q497T8
  4. NM_007691.6NP_031717.2  serine/threonine-protein kinase Chk1 isoform 1

    See identical proteins and their annotated locations for NP_031717.2

    Status: VALIDATED

    Source sequence(s)
    AC155921
    Consensus CDS
    CCDS22972.1
    UniProtKB/Swiss-Prot
    O35280, O54925, Q8CI40, Q9D0N2
    UniProtKB/TrEMBL
    Q497T8
    Related
    ENSMUSP00000034625.6, ENSMUST00000034625.12
    Conserved Domains (1) summary
    cd14069
    Location:7265
    STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    36619935..36637897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313117.3XP_017168606.1  serine/threonine-protein kinase Chk1 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1164
    PKc_like; Protein Kinases, catalytic domain