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Chek1 checkpoint kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 12649, updated on 6-Oct-2018

Summary

Official Symbol
Chek1provided by MGI
Official Full Name
checkpoint kinase 1provided by MGI
Primary source
MGI:MGI:1202065
See related
Ensembl:ENSMUSG00000032113 Vega:OTTMUSG00000037031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Chk1; rad27; C85740
Expression
Biased expression in CNS E11.5 (RPKM 8.0), liver E14 (RPKM 5.6) and 9 other tissues See more
Orthologs

Genomic context

See Chek1 in Genome Data Viewer
Location:
9; 9 A4
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (36708482..36726658, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (36516067..36534243, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700027I24 gene Neighboring gene acrosomal vesicle protein 1 Neighboring gene STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) Neighboring gene predicted gene, 26787 Neighboring gene etoposide induced 2.4 mRNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
histone kinase activity (H3-T11 specific) IDA
Inferred from Direct Assay
more info
PubMed 
histone kinase activity (H3-T11 specific) ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage checkpoint IDA
Inferred from Direct Assay
more info
PubMed 
DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
DNA damage induced protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
DNA repair ISO
Inferred from Sequence Orthology
more info
 
G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
apoptotic process involved in development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
chromatin-mediated maintenance of transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner cell mass cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
nucleus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of histone H3-K9 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic centrosome separation ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction involved in G2 DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
centrosome ISO
Inferred from Sequence Orthology
more info
 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
replication fork IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase Chk1
Names
CHK1 checkpoint homolog
checkpoint kinase 1 homolog
rad27 homolog
NP_031717.2
XP_017168606.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007691.5NP_031717.2  serine/threonine-protein kinase Chk1

    See identical proteins and their annotated locations for NP_031717.2

    Status: VALIDATED

    Source sequence(s)
    AK033179, AK045336, AK166675
    Consensus CDS
    CCDS22972.1
    UniProtKB/Swiss-Prot
    O35280
    Related
    ENSMUSP00000034625.5, OTTMUSP00000079376, ENSMUST00000034625.11, OTTMUST00000153349
    Conserved Domains (2) summary
    smart00220
    Location:9264
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14069
    Location:7265
    STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    36708482..36726658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313117.1XP_017168606.1  serine/threonine-protein kinase Chk1 isoform X1

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