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Cel carboxyl ester lipase [ Mus musculus (house mouse) ]

Gene ID: 12613, updated on 8-Feb-2024

Summary

Official Symbol
Celprovided by MGI
Official Full Name
carboxyl ester lipaseprovided by MGI
Primary source
MGI:MGI:88374
See related
Ensembl:ENSMUSG00000026818 AllianceGenome:MGI:88374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BAL; BSSL; 1810036E18Rik
Summary
Predicted to enable several functions, including carboxylic ester hydrolase activity; glycosphingolipid binding activity; and neurexin family protein binding activity. Acts upstream of or within ceramide catabolic process. Predicted to be located in several cellular components, including membrane raft; rough endoplasmic reticulum; and zymogen granule. Predicted to be part of protein-containing complex. Predicted to be active in cell surface and synapse. Predicted to be integral component of postsynaptic specialization membrane. Is expressed in several structures, including gut and mammary gland. Human ortholog(s) of this gene implicated in lipomatosis; maturity-onset diabetes of the young type 8; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human CEL (carboxyl ester lipase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 1159.1), spleen adult (RPKM 615.2) and 2 other tissues See more
Orthologs
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Genomic context

See Cel in Genome Data Viewer
Location:
2 A3; 2 19.38 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28445831..28453415, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28555819..28563403, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_04022 Neighboring gene STARR-positive B cell enhancer ABC_E10087 Neighboring gene ral guanine nucleotide dissociation stimulator Neighboring gene VISTA enhancer mm337 Neighboring gene general transcription factor IIIC, polypeptide 5 Neighboring gene STARR-positive B cell enhancer mm9_chr2:28440723-28441024 Neighboring gene predicted gene, 22675

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylesterase activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycosphingolipid binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables retinyl-palmitate esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables retinyl-palmitate esterase activity ISO
Inferred from Sequence Orthology
more info
 
enables sterol esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sterol esterase activity ISO
Inferred from Sequence Orthology
more info
 
enables triglyceride lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables triglyceride lipase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ceramide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ceramide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intestinal cholesterol absorption ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pancreatic juice secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pancreatic juice secretion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in zymogen granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bile salt-activated lipase
Names
bile salt-stimulated lipase
cholesterol esterase
pancreatic lysophospholipase
sterol esterase
NP_034015.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009885.2NP_034015.1  bile salt-activated lipase precursor

    See identical proteins and their annotated locations for NP_034015.1

    Status: VALIDATED

    Source sequence(s)
    AK131818, AL772249
    Consensus CDS
    CCDS15841.1
    UniProtKB/Swiss-Prot
    Q64285
    UniProtKB/TrEMBL
    Q3V2H7, Q922R3
    Related
    ENSMUSP00000028161.6, ENSMUST00000028161.6
    Conserved Domains (2) summary
    COG0657
    Location:117247
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:26542
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    28445831..28453415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)