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CNGA2 cyclic nucleotide gated channel subunit alpha 2 [ Homo sapiens (human) ]

Gene ID: 1260, updated on 9-Dec-2024

Summary

Official Symbol
CNGA2provided by HGNC
Official Full Name
cyclic nucleotide gated channel subunit alpha 2provided by HGNC
Primary source
HGNC:HGNC:2149
See related
Ensembl:ENSG00000183862 MIM:300338; AllianceGenome:HGNC:2149
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNCA; CNG2; CNCA1; OCNC1; OCNCa; OCNCALPHA
Summary
The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CNGA2 in Genome Data Viewer
Location:
Xq28
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (151734746..151745564)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (150003054..150013922)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (150903218..150914036)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene proline rich and Gla domain 3 Neighboring gene fetal and adult testis expressed 1 Neighboring gene NANOG hESC enhancer GRCh37_chrX:150993617-150994163 Neighboring gene MAGEA4 antisense RNA 1 Neighboring gene MAGE family member A4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ46312

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
 
enables cGMP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables intracellularly cAMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables intracellularly cGMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi-associated vesicle membrane TAS
Traceable Author Statement
more info
 
located_in ciliary membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in ciliary membrane TAS
Traceable Author Statement
more info
 
part_of intracellular cyclic nucleotide activated cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in non-motile cilium membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cyclic nucleotide-gated channel alpha-2
Names
CNG channel alpha-2
cyclic nucleotide gated channel alpha 2
cyclic nucleotide-gated olfactory channel
cyclic-nucleotide-gated cation channel 2
olfactory cyclic nucleotide-gated channel subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016352.1 RefSeqGene

    Range
    5001..15819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005140.3NP_005131.1  cyclic nucleotide-gated channel alpha-2

    See identical proteins and their annotated locations for NP_005131.1

    Status: REVIEWED

    Source sequence(s)
    AF002992
    Consensus CDS
    CCDS14701.1
    UniProtKB/Swiss-Prot
    A0AVD0, Q16280
    UniProtKB/TrEMBL
    B3KXY3
    Related
    ENSP00000328478.4, ENST00000329903.5
    Conserved Domains (5) summary
    COG0664
    Location:448632
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:454570
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:174382
    Ion_trans; Ion transport protein
    pfam16526
    Location:570639
    CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    cl18962
    Location:415468
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    151734746..151745564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    150003054..150013922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)