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CEACAM20 CEA cell adhesion molecule 20 [ Homo sapiens (human) ]

Gene ID: 125931, updated on 25-Jan-2022

Summary

Official Symbol
CEACAM20provided by HGNC
Official Full Name
CEA cell adhesion molecule 20provided by HGNC
Primary source
HGNC:HGNC:24879
See related
Ensembl:ENSG00000273777 AllianceGenome:HGNC:24879
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ9366
Summary
Predicted to be involved in positive regulation of cytokine production. Predicted to act upstream of or within response to bacterium. Predicted to be located in apical plasma membrane and microvillus membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in small intestine (RPKM 13.3), duodenum (RPKM 12.5) and 1 other tissue See more
Orthologs
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Genomic context

See CEACAM20 in Genome Data Viewer
Location:
19q13.31
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (44501309..44530101, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45010211..45033698, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 285B, pseudogene Neighboring gene zinc finger protein 180 Neighboring gene Sharpr-MPRA regulatory region 2061 Neighboring gene CEA cell adhesion molecule 22, pseudogene Neighboring gene CEACAM16, CEACAM19 and PVR antisense RNA 1 Neighboring gene immunoglobulin superfamily member 23 Neighboring gene Sharpr-MPRA regulatory region 2639

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 20
Names
GPAD9366
carcinoembryonic antigen related cell adhesion molecule 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102597.3NP_001096067.2  carcinoembryonic antigen-related cell adhesion molecule 20 isoform 5L precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5L) represents the longest transcript and encodes the longest isoform (5L).
    Source sequence(s)
    AC245748, AY358129, EU008600
    Consensus CDS
    CCDS74393.1
    UniProtKB/Swiss-Prot
    Q6UY09
    UniProtKB/TrEMBL
    A0A087WYM6, A7LFK7
    Related
    ENSP00000481937.1, ENST00000614924.5
    Conserved Domains (2) summary
    pfam13927
    Location:361420
    Ig_3; Immunoglobulin domain
    cl11960
    Location:266343
    Ig; Immunoglobulin domain
  2. NM_001102598.3NP_001096068.2  carcinoembryonic antigen-related cell adhesion molecule 20 isoform 4S precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4S) lacks an alternate in-frame exon in both the central and 3' coding regions, compared to variant 5L, resulting in an isoform (4S) that is shorter than isoform 5L.
    Source sequence(s)
    AC245748, AY358129, EU008600, EU008601
    Consensus CDS
    CCDS74390.1
    UniProtKB/Swiss-Prot
    Q6UY09
    UniProtKB/TrEMBL
    A0A087WYH6, A7LFK7, A7LFK8
    Related
    ENSP00000481812.1, ENST00000620096.4
    Conserved Domains (4) summary
    smart00410
    Location:175247
    IG_like; Immunoglobulin like
    pfam13895
    Location:175247
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:379435
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:266343
    Ig; Immunoglobulin domain
  3. NM_001102599.3NP_001096069.2  carcinoembryonic antigen-related cell adhesion molecule 20 isoform 4L precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4L) lacks an alternate in-frame exon in the central coding region, compared to variant 5L, resulting in an isoform (4L) that is shorter than isoform 5L.
    Source sequence(s)
    AC245748, AY358129, EU008600, EU008602
    Consensus CDS
    CCDS74391.1
    UniProtKB/Swiss-Prot
    Q6UY09
    UniProtKB/TrEMBL
    A0A087WZX4, A7LFK7, A7LFK9
    Related
    ENSP00000482943.1, ENST00000614577.4
    Conserved Domains (4) summary
    smart00410
    Location:175247
    IG_like; Immunoglobulin like
    pfam13895
    Location:175247
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:379434
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:266343
    Ig; Immunoglobulin domain
  4. NM_001102600.3NP_001096070.2  carcinoembryonic antigen-related cell adhesion molecule 20 isoform 5S precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5S) lacks an alternate in-frame exon in the 3' coding region, compared to variant 5L, resulting in an isoform (5S) that is shorter than isoform 5L.
    Source sequence(s)
    AC245748, AY358129, EU008600, EU008603
    Consensus CDS
    CCDS74392.1
    UniProtKB/Swiss-Prot
    Q6UY09
    UniProtKB/TrEMBL
    A0A087X155, A7LFK7, A7LFL0
    Related
    ENSP00000483912.1, ENST00000611497.4
    Conserved Domains (4) summary
    smart00410
    Location:361433
    IG_like; Immunoglobulin like
    pfam13895
    Location:369435
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:472528
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:266343
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    44501309..44530101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451345.1XP_024307113.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X2

    Conserved Domains (2) summary
    pfam13927
    Location:388447
    Ig_3; Immunoglobulin domain
    cl11960
    Location:293370
    Ig; Immunoglobulin domain
  2. XM_011526430.2XP_011524732.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X3

    Conserved Domains (4) summary
    smart00410
    Location:388460
    IG_like; Immunoglobulin like
    pfam13895
    Location:396462
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:499555
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:293370
    Ig; Immunoglobulin domain
  3. XM_011526429.2XP_011524731.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X1

    Conserved Domains (4) summary
    smart00410
    Location:388460
    IG_like; Immunoglobulin like
    pfam13895
    Location:396462
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:499554
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:293370
    Ig; Immunoglobulin domain
  4. XM_011526432.2XP_011524734.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X5

    Conserved Domains (4) summary
    smart00410
    Location:107179
    IG_like; Immunoglobulin like
    pfam13895
    Location:115181
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:218273
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:1289
    Ig; Immunoglobulin domain
  5. XM_011526431.2XP_011524733.1  carcinoembryonic antigen-related cell adhesion molecule 20 isoform X4

    Conserved Domains (4) summary
    smart00410
    Location:388460
    IG_like; Immunoglobulin like
    pfam13895
    Location:396462
    Ig_2; Immunoglobulin domain
    pfam16821
    Location:499554
    C_Hendra; C protein from hendra and measles viruses
    cl11960
    Location:293370
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198444.1: Suppressed sequence

    Description
    NM_198444.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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