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CLDND2 claudin domain containing 2 [ Homo sapiens (human) ]

Gene ID: 125875, updated on 4-Dec-2022

Summary

Official Symbol
CLDND2provided by HGNC
Official Full Name
claudin domain containing 2provided by HGNC
Primary source
HGNC:HGNC:28511
See related
Ensembl:ENSG00000160318 AllianceGenome:HGNC:28511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 2.4), bone marrow (RPKM 0.9) and 19 other tissues See more
Orthologs
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Genomic context

See CLDND2 in Genome Data Viewer
Location:
19q13.41
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51366739..51369003, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54455741..54457646, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51870352..51872257, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 10 like Neighboring gene electron transfer flavoprotein subunit beta Neighboring gene uncharacterized LOC124904752 Neighboring gene natural killer cell granule protein 7 Neighboring gene lens intrinsic membrane protein 2 Neighboring gene LIM2 and SIGLEC10 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC33839

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
claudin domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152353.3NP_689566.1  claudin domain-containing protein 2

    See identical proteins and their annotated locations for NP_689566.1

    Status: VALIDATED

    Source sequence(s)
    AC008750, BC029518
    Consensus CDS
    CCDS12829.1
    UniProtKB/Swiss-Prot
    Q8NHS1
    Related
    ENSP00000291715.1, ENST00000291715.5
    Conserved Domains (1) summary
    cl21598
    Location:10144
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51366739..51369003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438138.1XP_047294094.1  claudin domain-containing protein 2 isoform X1

  2. XM_047438137.1XP_047294093.1  claudin domain-containing protein 2 isoform X1

  3. XM_047438140.1XP_047294096.1  claudin domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8NHS1
    Related
    ENSP00000472077.1, ENST00000601435.1
  4. XM_047438139.1XP_047294095.1  claudin domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q8NHS1
  5. XM_011526428.3XP_011524730.1  claudin domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    cl21598
    Location:1069
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54455741..54457646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)