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Cdkn2b cyclin dependent kinase inhibitor 2B [ Mus musculus (house mouse) ]

Gene ID: 12579, updated on 20-Feb-2024

Summary

Official Symbol
Cdkn2bprovided by MGI
Official Full Name
cyclin dependent kinase inhibitor 2Bprovided by MGI
Primary source
MGI:MGI:104737
See related
Ensembl:ENSMUSG00000073802 AllianceGenome:MGI:104737
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p15; MTS2; INK4b; p15INK4b; p15(INK4b)
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and spleen development. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; immune system; lung; and retina. Human ortholog(s) of this gene implicated in carcinoma (multiple); erythema infectiosum; hematologic cancer (multiple); open-angle glaucoma; and urinary bladder cancer. Orthologous to human CDKN2B (cyclin dependent kinase inhibitor 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 85.1), colon adult (RPKM 73.4) and 10 other tissues See more
Orthologs
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Genomic context

See Cdkn2b in Genome Data Viewer
Location:
4 C4; 4 42.15 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (89224526..89229269, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (89306289..89311032, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene TGFB-induced factor homeobox 2, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_10736 Neighboring gene STARR-seq mESC enhancer starr_10737 Neighboring gene STARR-positive B cell enhancer ABC_E1646 Neighboring gene cyclin dependent kinase inhibitor 2A Neighboring gene STARR-seq mESC enhancer starr_10738 Neighboring gene STARR-positive B cell enhancer ABC_E11246 Neighboring gene predicted gene 12610 Neighboring gene STARR-seq mESC enhancer starr_10739 Neighboring gene STARR-seq mESC enhancer starr_10740 Neighboring gene VISTA enhancer mm10 Neighboring gene STARR-seq mESC enhancer starr_10741 Neighboring gene heat shock protein 1 (chaperonin) pseudogene 8 Neighboring gene predicted gene, 54238

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to extracellular stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nutrient ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G0 to G1 transition ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spleen development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 4 inhibitor B
Names
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
cyclin-dependent kinase inhibitor p15
cyclin-dependent kinase inhibitor p15INK4b
cyclin-dependent kinase inhibitor protein
p14-INK4b
p15-INK4b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007670.4NP_031696.1  cyclin-dependent kinase 4 inhibitor B

    See identical proteins and their annotated locations for NP_031696.1

    Status: VALIDATED

    Source sequence(s)
    AF059567, CAAA01036593, DT919921
    Consensus CDS
    CCDS18351.1
    UniProtKB/Swiss-Prot
    P55271
    UniProtKB/TrEMBL
    Q3UNM8, Q549R4
    Related
    ENSMUSP00000095595.5, ENSMUST00000097981.6
    Conserved Domains (3) summary
    cd00204
    Location:13124
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:10102
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:1036
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    89224526..89229269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)