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Cdh1 cadherin 1 [ Mus musculus (house mouse) ]

Gene ID: 12550, updated on 12-Aug-2018
Official Symbol
Cdh1provided by MGI
Official Full Name
cadherin 1provided by MGI
Primary source
MGI:MGI:88354
See related
Ensembl:ENSMUSG00000000303 Vega:OTTMUSG00000020588
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Um; UVO; Ecad; ARC-1; E-cad; L-CAM; AA960649
Summary
This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related cadherin gene on chromosome 8. [provided by RefSeq, Oct 2015]
Annotation information
Note: CDH1 (GeneID 12550) and FZR1 (GeneID 56371) share the CDH1 symbol. CDH1 is sometimes used as an abbreviation for 'CDC20 homolog 1' which is an alternate name for the FZR1 gene and thus can be confused with the official symbol for cadherin 1 (CDH1). [16 Jul 2018]
Expression
Broad expression in colon adult (RPKM 139.2), large intestine adult (RPKM 100.0) and 15 other tissues See more
Orthologs
See Cdh1 in Genome Data Viewer
Location:
8 D3; 8 53.18 cM
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (106603350..106670247)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (109127268..109194146)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110028F18 gene Neighboring gene ribosomal protein, large, P1 pseudogene Neighboring gene predicted gene, 39239 Neighboring gene transport and golgi organization 6 Neighboring gene predicted gene, 34197 Neighboring gene hyaluronan synthase 3

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC107495

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
 
alpha-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
ankyrin binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
cytoskeletal protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeletal protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction organization ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to indole-3-methanol ISO
Inferred from Sequence Orthology
more info
 
cellular response to lithium ion ISO
Inferred from Sequence Orthology
more info
 
cochlea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
decidualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intestinal epithelial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neuron migration IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of water loss via skin IMP
Inferred from Mutant Phenotype
more info
PubMed 
salivary gland cavitation IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse assembly ISO
Inferred from Sequence Orthology
more info
 
trophectodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
uterine epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
apical junction complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apical junction complex IDA
Inferred from Direct Assay
more info
PubMed 
apical junction complex ISO
Inferred from Sequence Orthology
more info
 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catenin complex IDA
Inferred from Direct Assay
more info
PubMed 
catenin complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
catenin complex ISO
Inferred from Sequence Orthology
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
flotillin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
flotillin complex IDA
Inferred from Direct Assay
more info
PubMed 
flotillin complex ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
lateral loop IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
node of Ranvier IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cadherin-1
Names
E-cadherin
epithelial cadherin
uvomorulin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009864.3NP_033994.1  cadherin-1 preproprotein

    See identical proteins and their annotated locations for NP_033994.1

    Status: REVIEWED

    Source sequence(s)
    AC132132, AC147500, AK076369, BP765198, CF898038
    Consensus CDS
    CCDS22638.1
    UniProtKB/Swiss-Prot
    P09803
    UniProtKB/TrEMBL
    A0A0R4IZW5
    Related
    ENSMUSP00000000312.5, OTTMUSP00000022465, ENSMUST00000000312.11, OTTMUST00000048788
    Conserved Domains (6) summary
    cd00031
    Location:160260
    CA_like; Cadherin repeat-like domain
    cd11304
    Location:268373
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam00028
    Location:382461
    Cadherin; Cadherin domain
    pfam01049
    Location:743879
    Cadherin_C; Cadherin cytoplasmic region
    pfam08758
    Location:29118
    Cadherin_pro; Cadherin prodomain like
    cl09101
    Location:606688
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    106603350..106670247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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