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SLC5A10 solute carrier family 5 member 10 [ Homo sapiens (human) ]

Gene ID: 125206, updated on 23-Nov-2021

Summary

Official Symbol
SLC5A10provided by HGNC
Official Full Name
solute carrier family 5 member 10provided by HGNC
Primary source
HGNC:HGNC:23155
See related
Ensembl:ENSG00000154025 MIM:618636
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGLT5; SGLT-5
Summary
This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Biased expression in kidney (RPKM 27.8), skin (RPKM 6.0) and 1 other tissue See more
Orthologs
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Genomic context

See SLC5A10 in Genome Data Viewer
Location:
17p11.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (18950676..19022565)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18853989..18925878)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain-containing protein 144A-like Neighboring gene RNA, 7SL, cytoplasmic 627, pseudogene Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 2 Neighboring gene RAN binding protein 1 pseudogene Neighboring gene family with sequence similarity 83 member G Neighboring gene GRB2 related adaptor protein Neighboring gene uncharacterized LOC112268188 Neighboring gene small nucleolar RNA, C/D box 3B-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glucose:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables solute:sodium symporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in hexose transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium/glucose cotransporter 5
Names
Na(+)/glucose cotransporter 5
solute carrier family 5 (sodium/glucose cotransporter), member 10
solute carrier family 5 (sodium/sugar cotransporter), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042450.4NP_001035915.1  sodium/glucose cotransporter 5 isoform 2

    See identical proteins and their annotated locations for NP_001035915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AA745934, AC003957, BC034380, BP332461, DR003789
    Consensus CDS
    CCDS42275.1
    UniProtKB/Swiss-Prot
    A0PJK1
    Related
    ENSP00000379007.3, ENST00000395645.4
    Conserved Domains (1) summary
    cd11489
    Location:17596
    SLC5sbd_SGLT5; Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain
  2. NM_001270648.3NP_001257577.1  sodium/glucose cotransporter 5 isoform 3

    See identical proteins and their annotated locations for NP_001257577.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AA745934, AC003957, BC062617, BP332461
    Consensus CDS
    CCDS59278.1
    UniProtKB/Swiss-Prot
    A0PJK1
    Related
    ENSP00000379005.2, ENST00000395643.6
    Conserved Domains (1) summary
    cl00456
    Location:17569
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. NM_001270649.2NP_001257578.1  sodium/glucose cotransporter 5 isoform 4

    See identical proteins and their annotated locations for NP_001257578.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AA745934, AC003957, AK298345, BC062617, BP332461, DR003789
    Consensus CDS
    CCDS59277.1
    UniProtKB/Swiss-Prot
    A0PJK1
    Related
    ENSP00000401875.2, ENST00000417251.6
    Conserved Domains (1) summary
    cl00456
    Location:17560
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. NM_001282417.1NP_001269346.1  sodium/glucose cotransporter 5 isoform 5

    See identical proteins and their annotated locations for NP_001269346.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has many differences in the coding region but maintains the reading frame compared to variant 1. This variant encodes isoform 5, which has a shorter N-terminus and is shorter compared to isoform 1.
    Source sequence(s)
    AA745934, BC034380, BC039868
    Consensus CDS
    CCDS74008.1
    UniProtKB/Swiss-Prot
    A0PJK1
    Related
    ENSP00000324346.6, ENST00000317977.10
    Conserved Domains (1) summary
    cl00456
    Location:1566
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  5. NM_152351.6NP_689564.3  sodium/glucose cotransporter 5 isoform 1

    See identical proteins and their annotated locations for NP_689564.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA745934, AC003957, AK057946, BC034380
    Consensus CDS
    CCDS11201.2
    UniProtKB/Swiss-Prot
    A0PJK1
    Related
    ENSP00000379008.2, ENST00000395647.6
    Conserved Domains (1) summary
    cd11489
    Location:17612
    SLC5sbd_SGLT5; Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    18950676..19022565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024191.2XP_016879680.2  sodium/glucose cotransporter 5 isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:17649
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_011523652.2XP_011521954.2  sodium/glucose cotransporter 5 isoform X2

    Conserved Domains (1) summary
    cd11489
    Location:17633
    SLC5sbd_SGLT5; Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain
  3. XM_011523653.3XP_011521955.2  sodium/glucose cotransporter 5 isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:17622
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
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