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Cd4 CD4 antigen [ Mus musculus (house mouse) ]

Gene ID: 12504, updated on 26-Nov-2019

Summary

Official Symbol
Cd4provided by MGI
Official Full Name
CD4 antigenprovided by MGI
Primary source
MGI:MGI:88335
See related
Ensembl:ENSMUSG00000023274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L3T4; Ly-4
Expression
Biased expression in thymus adult (RPKM 167.0), spleen adult (RPKM 15.0) and 1 other tissue See more
Orthologs

Genomic context

See Cd4 in Genome Data Viewer
Location:
6 F2; 6 59.17 cM
Exon count:
10
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124864693..124888247, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (124814711..124838227, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene predicted gene, 32404 Neighboring gene G protein-coupled receptor 162 Neighboring gene lymphocyte-activation gene 3 Neighboring gene RIKEN cDNA A230083G16 gene Neighboring gene parathymosin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
MHC class II protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MHC class II protein binding ISO
Inferred from Sequence Orthology
more info
 
coreceptor activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
immunoglobulin binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-16 binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-16 receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell activation ISO
Inferred from Sequence Orthology
more info
 
T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
T cell selection ISO
Inferred from Sequence Orthology
more info
 
T cell selection ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
helper T cell enhancement of adaptive immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
induction by virus of host cell-cell fusion ISO
Inferred from Sequence Orthology
more info
 
interleukin-15-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-15-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
maintenance of protein location in cell ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-cell surface glycoprotein CD4
Names
T-cell differentiation antigen L3T4
T-cell surface antigen T4/Leu-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013488.3NP_038516.1  T-cell surface glycoprotein CD4 precursor

    See identical proteins and their annotated locations for NP_038516.1

    Status: VALIDATED

    Source sequence(s)
    AK153707, AK161775, BX639790
    Consensus CDS
    CCDS20535.1
    UniProtKB/Swiss-Prot
    P06332
    UniProtKB/TrEMBL
    Q3TSV7
    Related
    ENSMUSP00000024044.6, ENSMUST00000024044.6
    Conserved Domains (5) summary
    smart00410
    Location:131205
    IG_like; Immunoglobulin like
    pfam05790
    Location:128207
    C2-set; Immunoglobulin C2-set domain
    pfam09191
    Location:212316
    CD4-extracel; CD4, extracellular
    pfam12104
    Location:425452
    Tcell_CD4_C; T cell CD4 receptor C terminal region
    cl11960
    Location:29124
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p6 C57BL/6J

    Range
    124864693..124888247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505462.2XP_006505525.1  T-cell surface glycoprotein CD4 isoform X2

    Conserved Domains (4) summary
    smart00410
    Location:131205
    IG_like; Immunoglobulin like
    pfam05790
    Location:128207
    C2-set; Immunoglobulin C2-set domain
    pfam09191
    Location:212316
    CD4-extracel; CD4, extracellular
    cl11960
    Location:29124
    Ig; Immunoglobulin domain
  2. XM_006505461.4XP_006505524.1  T-cell surface glycoprotein CD4 isoform X1

    Conserved Domains (4) summary
    smart00410
    Location:131205
    IG_like; Immunoglobulin like
    pfam05790
    Location:128207
    C2-set; Immunoglobulin C2-set domain
    pfam09191
    Location:212316
    CD4-extracel; CD4, extracellular
    cl11960
    Location:29124
    Ig; Immunoglobulin domain
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