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Cd3e CD3 antigen, epsilon polypeptide [ Mus musculus (house mouse) ]

Gene ID: 12501, updated on 1-Mar-2024

Summary

Official Symbol
Cd3eprovided by MGI
Official Full Name
CD3 antigen, epsilon polypeptideprovided by MGI
Primary source
MGI:MGI:88332
See related
Ensembl:ENSMUSG00000032093 AllianceGenome:MGI:88332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD3; T3e; CD3epsilon
Summary
Predicted to enable several functions, including SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in nervous system development and positive regulation of cell adhesion. Acts upstream of or within several processes, including positive regulation of T cell activation; positive regulation of cytokine production; and regulation of signal transduction. Located in several cellular components, including dendritic spine; external side of plasma membrane; and immunological synapse. Part of alpha-beta T cell receptor complex. Is expressed in colon and hemolymphoid system. Human ortholog(s) of this gene implicated in immunodeficiency 18. Orthologous to human CD3E (CD3e molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 115.4), spleen adult (RPKM 18.7) and 1 other tissue See more
Orthologs
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Genomic context

See Cd3e in Genome Data Viewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44910033..44920961, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44998735..45009663, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CD3 antigen, gamma polypeptide Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794321-44794504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794585-44794829 Neighboring gene CD3 antigen, delta polypeptide Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44804746-44804978 Neighboring gene STARR-seq mESC enhancer starr_23989 Neighboring gene STARR-positive B cell enhancer mm9_chr9:44849180-44849480 Neighboring gene myelin protein zero-like 2 Neighboring gene STARR-seq mESC enhancer starr_23990 Neighboring gene myelin protein zero-like 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of CD4-positive, alpha-beta T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of T cell anergy IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within T cell costimulation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of interleukin-4 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lymphocyte activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative thymic T cell selection IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell anergy IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell-cell adhesion mediated by integrin IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell-matrix adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-2 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-4 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive thymic T cell selection IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to nutrient ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of T cell receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of alpha-beta T cell receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of alpha-beta T cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of alpha-beta T cell receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-cell surface glycoprotein CD3 epsilon chain
Names
T-cell surface antigen T3/Leu-4 epsilon chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007648.5NP_031674.1  T-cell surface glycoprotein CD3 epsilon chain precursor

    See identical proteins and their annotated locations for NP_031674.1

    Status: VALIDATED

    Source sequence(s)
    AC122305
    Consensus CDS
    CCDS23125.1
    UniProtKB/Swiss-Prot
    P22646
    UniProtKB/TrEMBL
    A6H6M1, B0LAX5
    Related
    ENSMUSP00000099896.2, ENSMUST00000102832.3
    Conserved Domains (2) summary
    smart00077
    Location:167187
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam16681
    Location:29108
    Ig_5; Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44910033..44920961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509966.4XP_006510029.1  T-cell surface glycoprotein CD3 epsilon chain isoform X1

    See identical proteins and their annotated locations for XP_006510029.1

    UniProtKB/Swiss-Prot
    P22646
    UniProtKB/TrEMBL
    A6H6M1, B0LAX5
    Conserved Domains (2) summary
    smart00077
    Location:167187
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam16681
    Location:29108
    Ig_5; Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain