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Cd3e CD3 antigen, epsilon polypeptide [ Mus musculus (house mouse) ]

Gene ID: 12501, updated on 4-Jun-2019

Summary

Official Symbol
Cd3eprovided by MGI
Official Full Name
CD3 antigen, epsilon polypeptideprovided by MGI
Primary source
MGI:MGI:88332
See related
Ensembl:ENSMUSG00000032093
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD3; T3e; AI504783; CD3epsilon
Expression
Biased expression in thymus adult (RPKM 115.4), spleen adult (RPKM 18.7) and 1 other tissue See more
Orthologs

Genomic context

See Cd3e in Genome Data Viewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (44998735..45009664, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (44806826..44817673, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene CD3 antigen, gamma polypeptide Neighboring gene CD3 antigen, delta polypeptide Neighboring gene myelin protein zero-like 2 Neighboring gene myelin protein zero-like 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Chemically induced (ENU) (2) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
T cell costimulation IGI
Inferred from Genetic Interaction
more info
PubMed 
T cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
lymphocyte activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative thymic T cell selection IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell anergy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of alpha-beta T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell-cell adhesion mediated by integrin IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell-matrix adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-2 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-4 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive thymic T cell selection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
response to nutrient ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
T cell receptor complex ISO
Inferred from Sequence Orthology
more info
 
alpha-beta T cell receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha-beta T cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
cell body IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-cell surface glycoprotein CD3 epsilon chain
Names
T-cell surface antigen T3/Leu-4 epsilon chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007648.5NP_031674.1  T-cell surface glycoprotein CD3 epsilon chain precursor

    See identical proteins and their annotated locations for NP_031674.1

    Status: VALIDATED

    Source sequence(s)
    AC122305
    Consensus CDS
    CCDS23125.1
    UniProtKB/Swiss-Prot
    P22646
    UniProtKB/TrEMBL
    A6H6M1
    Related
    ENSMUSP00000099896.1, ENSMUST00000102832.2
    Conserved Domains (3) summary
    smart00077
    Location:167187
    ITAM; Immunoreceptor tyrosine-based activation motif
    smart00410
    Location:3583
    IG_like; Immunoglobulin like
    pfam16681
    Location:29103
    Ig_5; Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    44998735..45009664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509966.3XP_006510029.1  T-cell surface glycoprotein CD3 epsilon chain isoform X1

    See identical proteins and their annotated locations for XP_006510029.1

    UniProtKB/Swiss-Prot
    P22646
    UniProtKB/TrEMBL
    A6H6M1
    Conserved Domains (3) summary
    smart00077
    Location:167187
    ITAM; Immunoreceptor tyrosine-based activation motif
    smart00410
    Location:3583
    IG_like; Immunoglobulin like
    pfam16681
    Location:29103
    Ig_5; Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain
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