U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cct5 chaperonin containing TCP1 subunit 5 [ Mus musculus (house mouse) ]

Gene ID: 12465, updated on 1-Mar-2024

Summary

Official Symbol
Cct5provided by MGI
Official Full Name
chaperonin containing TCP1 subunit 5provided by MGI
Primary source
MGI:MGI:107185
See related
Ensembl:ENSMUSG00000022234 AllianceGenome:MGI:107185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccte; TCPE; mKIAA0098; CCT-epsilon; TCP-1-epsilon
Summary
Predicted to enable several functions, including G-protein beta-subunit binding activity; beta-tubulin binding activity; and mRNA binding activity. Acts upstream of or within binding activity of sperm to zona pellucida and toxin transport. Located in cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in 1st branchial arch mandibular component and mandible primordium. Orthologous to human CCT5 (chaperonin containing TCP1 subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 143.9), placenta adult (RPKM 109.5) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cct5 in Genome Data Viewer
Location:
15 B2; 15 13.02 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (31590946..31601992, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (31590800..31601846, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 49208 Neighboring gene membrane associated ring-CH-type finger 6 Neighboring gene STARR-seq mESC enhancer starr_38292 Neighboring gene carboxymethylenebutenolidase homolog Neighboring gene STARR-positive B cell enhancer ABC_E4130 Neighboring gene ATP synthase C subunit lysine N-methyltransferase Neighboring gene predicted gene, 32383

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables G-protein beta-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 5'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperonin-containing T-complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 

General protein information

Preferred Names
T-complex protein 1 subunit epsilon
Names
chaperonin containing Tcp1, subunit 5 (epsilon)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348035.1NP_001334964.1  T-complex protein 1 subunit epsilon isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC137842, BC094427, BY579491, CX238090
    UniProtKB/Swiss-Prot
    P80316
    Conserved Domains (1) summary
    cd03339
    Location:1497
    TCP1_epsilon; TCP-1 (CTT or eukaryotic type II) chaperonin family, epsilon subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
  2. NM_007637.3NP_031663.1  T-complex protein 1 subunit epsilon isoform 1

    See identical proteins and their annotated locations for NP_031663.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC094427, BY579491, CJ086704
    Consensus CDS
    CCDS27411.1
    UniProtKB/Swiss-Prot
    P80316, Q3TIE0, Q3U530, Q3UCU4, Q3UJK9, Q3UWA9, Q542K3, Q6ZQJ1
    Related
    ENSMUSP00000022842.9, ENSMUST00000022842.16
    Conserved Domains (2) summary
    cd03339
    Location:10535
    TCP1_epsilon; TCP-1 (CTT or eukaryotic type II) chaperonin family, epsilon subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    pfam00118
    Location:44533
    Cpn60_TCP1; TCP-1/cpn60 chaperonin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    31590946..31601992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)