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Ccne1 cyclin E1 [ Mus musculus (house mouse) ]

Gene ID: 12447, updated on 8-Feb-2024

Summary

Official Symbol
Ccne1provided by MGI
Official Full Name
cyclin E1provided by MGI
Primary source
MGI:MGI:88316
See related
Ensembl:ENSMUSG00000002068 AllianceGenome:MGI:88316
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CycE1
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; and protein kinase binding activity. Acts upstream of or within several processes, including DNA metabolic process; homologous chromosome pairing at meiosis; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of cyclin E1-CDK2 complex. Is expressed in several structures, including brain; early conceptus; embryo ectoderm; eye; and spinal cord. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to human CCNE1 (cyclin E1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 46.5), liver E14.5 (RPKM 42.0) and 16 other tissues See more
Orthologs
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Genomic context

See Ccne1 in Genome Data Viewer
Location:
7 B3; 7 25.35 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (37797409..37806915, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (38097984..38107490, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8166 Neighboring gene URI1, prefoldin-like chaperone Neighboring gene STARR-positive B cell enhancer ABC_E6537 Neighboring gene STARR-seq mESC enhancer starr_18677 Neighboring gene predicted gene, 30684 Neighboring gene predicted gene, 30771 Neighboring gene STARR-positive B cell enhancer ABC_E8167 Neighboring gene STARR-positive B cell enhancer ABC_E4920 Neighboring gene predicted gene, 30912 Neighboring gene STARR-seq mESC enhancer starr_18684 Neighboring gene predicted gene, 22203

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromosome organization involved in meiotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mesenchymal stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of protein localization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within telomere maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin E1-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cyclin E1-CDK2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007633.2NP_031659.2  G1/S-specific cyclin-E1

    See identical proteins and their annotated locations for NP_031659.2

    Status: VALIDATED

    Source sequence(s)
    BC106191
    Consensus CDS
    CCDS39914.1
    UniProtKB/Swiss-Prot
    Q05BA1, Q05BA6, Q05BB7, Q61457
    UniProtKB/TrEMBL
    B2RS11
    Related
    ENSMUSP00000103658.4, ENSMUST00000108023.10
    Conserved Domains (2) summary
    pfam00134
    Location:113240
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:243362
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    37797409..37806915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)