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Ccnd3 cyclin D3 [ Mus musculus (house mouse) ]

Gene ID: 12445, updated on 2-Nov-2024

Summary

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Official Symbol
Ccnd3provided by MGI
Official Full Name
cyclin D3provided by MGI
Primary source
MGI:MGI:88315
See related
Ensembl:ENSMUSG00000034165 AllianceGenome:MGI:88315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9230106B05Rik
Summary
Enables cyclin-dependent protein serine/threonine kinase activity and protein kinase binding activity. Acts upstream of or within several processes, including T cell proliferation; negative regulation of transcription by RNA polymerase II; and regulation of cell population proliferation. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; eye; and gonad. Orthologous to human CCND3 (cyclin D3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 402.8), adrenal adult (RPKM 319.1) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Ccnd3 in Genome Data Viewer
Location:
17 C; 17 23.37 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47815976..47910614)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47505051..47599689)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ciliary microtubule inner protein 3 Neighboring gene STARR-seq mESC enhancer starr_42703 Neighboring gene expressed sequence AI661453 Neighboring gene STARR-positive B cell enhancer ABC_E9168 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47641447-47641630 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47641910-47642097 Neighboring gene STARR-positive B cell enhancer ABC_E5616 Neighboring gene STARR-seq mESC enhancer starr_42710 Neighboring gene TATA-box binding protein associated factor 8 Neighboring gene STARR-positive B cell enhancer ABC_E10958 Neighboring gene VISTA enhancer mm1691 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47668330-47668738 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47679075-47679320 Neighboring gene predicted gene, 41590 Neighboring gene STARR-seq mESC enhancer starr_42717 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47732923-47733032 Neighboring gene STARR-positive B cell enhancer ABC_E9169 Neighboring gene STARR-positive B cell enhancer ABC_E10959 Neighboring gene bystin-like Neighboring gene predicted gene 20517 Neighboring gene Kpna2 retrotransposed pseudogene Neighboring gene mediator complex subunit 20 Neighboring gene ubiquitin specific peptidase 49 Neighboring gene translocase of outer mitochondrial membrane 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulated Capture of Vκ Gene Topologically Associating Domains by Transcription Factories. Karki S, et al. Cell Rep, 2018 Aug 28. PMID 30157436, Free PMC Article
  2. Gamma-amino butyric acid and the A-type receptor suppress decidualization of mouse uterine stromal cells by down-regulating cyclin D3. Luo W, et al. Mol Reprod Dev, 2013 Jan. PMID 23150429
  3. Cell cycle regulatory control for uterine stromal cell decidualization in implantation. Das SK. Reproduction, 2009 Jun. PMID 19307426
  4. Lack of cyclin D3 induces skeletal muscle fiber-type shifting, increased endurance performance and hypermetabolism. Giannattasio S, et al. Sci Rep, 2018 Aug 24. PMID 30143714, Free PMC Article
  5. Cyclin D3 deficiency promotes a slower, more oxidative skeletal muscle phenotype and ameliorates pathophysiology in the mdx mouse model of Duchenne muscular dystrophy. Bonato A, et al. FASEB J, 2023 Jul. PMID 37309599

See all (238) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Cyclin D3 Protein Enforces Monogenic TCRbeta Expression by Mediating TCRbeta Protein-Signaled Feedback Inhibition of Vbeta Recombination.
    Title: The Cyclin D3 Protein Enforces Monogenic TCRβ Expression by Mediating TCRβ Protein-Signaled Feedback Inhibition of Vβ Recombination.
  2. IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation.
    Title: IL-21 shapes germinal center polarization via light zone B cell selection and cyclin D3 upregulation.
  3. Cyclin D3 deficiency promotes a slower, more oxidative skeletal muscle phenotype and ameliorates pathophysiology in the mdx mouse model of Duchenne muscular dystrophy.
    Title: Cyclin D3 deficiency promotes a slower, more oxidative skeletal muscle phenotype and ameliorates pathophysiology in the mdx mouse model of Duchenne muscular dystrophy.
  4. Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells.
    Title: Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells.
  5. Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells.
    Title: Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells.
  6. cyclin D3 regulates muscle fiber type phenotype.
    Title: Lack of cyclin D3 induces skeletal muscle fiber-type shifting, increased endurance performance and hypermetabolism.
  7. Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.
    Title: The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells.
  8. These results suggest that progesterone receptor overexpression in endometrial stromal cells, likely due to high progesterone levels, triggers cyclin D3 and Hoxa-10 overexpression, which may be involved in the pathological mechanisms of the mouse uterine decidual reaction.
    Title: Hoxa-10 and Cyclin D3 Overexpression in the Decidual Reaction in a Superovulation Protocol in Young Adult C57BL/6J Mice.
  9. the activation of TLR7 increased CCND3 expression via the downregulation of miR-15b in B cells.
    Title: Activation of TLR7 increases CCND3 expression via the downregulation of miR-15b in B cells of systemic lupus erythematosus.
  10. immature B and T cells use lymphocyte lineage- and developmental stage-specific mechanisms to inhibit Cyclin D3 protein levels.
    Title: Lymphocyte lineage-specific and developmental stage specific mechanisms suppress cyclin D3 expression in response to DNA double strand breaks.
Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to peptide hormone ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin D3-CDK4 complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin D3-CDK6 complex IEA
Inferred from Electronic Annotation
more info
  
part_of cyclin D3-CDK6 complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
G1/S-specific cyclin-D3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081635.1 → NP_001075104.1  G1/S-specific cyclin-D3

    See identical proteins and their annotated locations for NP_001075104.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, compared to variant 3. Variant 2 encodes the same protein as variant 3.
    Source sequence(s)
    AK159503, AK161758, AK210362, BQ033424, BY146822, M86183
    Consensus CDS
    CCDS28850.1
    UniProtKB/Swiss-Prot
    P30282, Q62391, Q99KP2
    UniProtKB/TrEMBL
    Q3TSW4, Q3TWY0
    Related
    ENSMUSP00000040488.10, ENSMUST00000037333.17
    Conserved Domains (1) summary
    cl40454
    Location:2 → 151
    CYCLIN_SF; Cyclin box fold superfamily

  2. NM_001081636.1 → NP_001075105.1  G1/S-specific cyclin-D3

    See identical proteins and their annotated locations for NP_001075105.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK159503, AK161758, AK210362, BQ033424, BY146822, M86183
    Consensus CDS
    CCDS28850.1
    UniProtKB/Swiss-Prot
    P30282, Q62391, Q99KP2
    UniProtKB/TrEMBL
    Q3TSW4, Q3TWY0
    Related
    ENSMUSP00000126141.2, ENSMUST00000171031.8
    Conserved Domains (1) summary
    cl40454
    Location:2 → 151
    CYCLIN_SF; Cyclin box fold superfamily

  3. NM_007632.2 → NP_031658.1  G1/S-specific cyclin-D3

    See identical proteins and their annotated locations for NP_031658.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variant 1 encodes the same protein as variant 3.
    Source sequence(s)
    AK159503, AK210362, BQ033424, BY142612, M86183
    Consensus CDS
    CCDS28850.1
    UniProtKB/Swiss-Prot
    P30282, Q62391, Q99KP2
    UniProtKB/TrEMBL
    Q3TSW4, Q3TWY0
    Related
    ENSMUSP00000138091.2, ENSMUST00000182209.8
    Conserved Domains (1) summary
    cl40454
    Location:2 → 151
    CYCLIN_SF; Cyclin box fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47815976..47910614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523552.2 → XP_006523615.1  G1/S-specific cyclin-D3 isoform X1

    Conserved Domains (1) summary
    cl40454
    Location:92 → 196
    CYCLIN_SF; Cyclin box fold superfamily

  2. XM_011246262.1 → XP_011244564.1  G1/S-specific cyclin-D3 isoform X3

    See identical proteins and their annotated locations for XP_011244564.1

    Conserved Domains (2) summary
    pfam00134
    Location:19 → 105
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:107 → 203
    Cyclin_C; Cyclin, C-terminal domain

  3. XM_006523553.5 → XP_006523616.1  G1/S-specific cyclin-D3 isoform X2

    UniProtKB/TrEMBL
    S4R216
    Related
    ENSMUSP00000138458.2, ENSMUST00000182539.8
    Conserved Domains (1) summary
    pfam02984
    Location:1 → 55
    Cyclin_C; Cyclin, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30282.1 GenPept UniProtKB/Swiss-Prot:P30282

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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