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TMEM219 transmembrane protein 219 [ Homo sapiens (human) ]

Gene ID: 124446, updated on 2-Oct-2018

Summary

Official Symbol
TMEM219provided by HGNC
Official Full Name
transmembrane protein 219provided by HGNC
Primary source
HGNC:HGNC:25201
See related
Ensembl:ENSG00000149932 Vega:OTTHUMG00000177105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGFBP-3R
Expression
Ubiquitous expression in testis (RPKM 42.5), small intestine (RPKM 28.6) and 25 other tissues See more
Orthologs

Genomic context

See TMEM219 in Genome Data Viewer
Location:
16p11.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (29962030..29973052)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29973351..29984373)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene aspartate beta-hydroxylase domain containing 1 Neighboring gene potassium channel tetramerization domain containing 13 Neighboring gene uncharacterized LOC107984836 Neighboring gene TAO kinase 2 Neighboring gene HIRA interacting protein 3 Neighboring gene INO80 complex subunit E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • TP53 Regulates Transcription of Cell Death Genes, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Cell Death Genes, organism-specific biosystemThe tumor suppressor TP53 (p53) exerts its tumor suppressive role in part by regulating transcription of a number of genes involved in cell death, mainly apoptotic cell death. The majority of apoptot...
  • TP53 Regulates Transcription of Death Receptors and Ligands, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Death Receptors and Ligands, organism-specific biosystemPro-apoptotic transcriptional targets of TP53 are TRAIL death receptors TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2), as well as the FASL/CD95L death receptor FAS (CD95). T...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
insulin-like growth factor-binding protein 3 receptor
Names
testicular tissue protein Li 203

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083613.1NP_001077082.1  insulin-like growth factor-binding protein 3 receptor precursor

    See identical proteins and their annotated locations for NP_001077082.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC050051, CF453990, DB506492
    Consensus CDS
    CCDS42145.1
    UniProtKB/Swiss-Prot
    Q86XT9
    UniProtKB/TrEMBL
    A0A024R618
    Related
    ENSP00000279396.6, ENST00000279396.10
    Conserved Domains (1) summary
    pfam14940
    Location:48169
    TMEM219; Transmembrane 219
  2. NM_194280.3NP_919256.1  insulin-like growth factor-binding protein 3 receptor precursor

    See identical proteins and their annotated locations for NP_919256.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC050051, BF724791, CF453990, DB506492
    Consensus CDS
    CCDS42145.1
    UniProtKB/Swiss-Prot
    Q86XT9
    UniProtKB/TrEMBL
    A0A024R618
    Related
    ENSP00000388485.2, OTTHUMP00000272203, ENST00000414689.6, OTTHUMT00000467597
    Conserved Domains (1) summary
    pfam14940
    Location:48169
    TMEM219; Transmembrane 219

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    29962030..29973052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255123.1XP_005255180.1  insulin-like growth factor-binding protein 3 receptor isoform X1

    See identical proteins and their annotated locations for XP_005255180.1

    UniProtKB/Swiss-Prot
    Q86XT9
    UniProtKB/TrEMBL
    A0A024R618
    Related
    ENSP00000459813.1, OTTHUMP00000257363, ENST00000570255.5, OTTHUMT00000435310
    Conserved Domains (1) summary
    pfam14940
    Location:48169
    TMEM219; Transmembrane 219

RNA

  1. XR_429673.2 RNA Sequence

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