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TMEM219 transmembrane protein 219 [ Homo sapiens (human) ]

Gene ID: 124446, updated on 22-Sep-2022

Summary

Official Symbol
TMEM219provided by HGNC
Official Full Name
transmembrane protein 219provided by HGNC
Primary source
HGNC:HGNC:25201
See related
Ensembl:ENSG00000149932 AllianceGenome:HGNC:25201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGFBP-3R
Summary
Predicted to be involved in apoptotic process. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 42.5), small intestine (RPKM 28.6) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM219 in Genome Data Viewer
Location:
16p11.2
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (29962079..29973048)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (30244712..30255683)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (29973400..29984369)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene aspartate beta-hydroxylase domain containing 1 Neighboring gene potassium channel tetramerization domain containing 13 Neighboring gene KCTD13 divergent transcript Neighboring gene uncharacterized LOC124903762 Neighboring gene TAO kinase 2 Neighboring gene HIRA interacting protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
insulin-like growth factor-binding protein 3 receptor
Names
testicular tissue protein Li 203

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083613.2NP_001077082.1  insulin-like growth factor-binding protein 3 receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001077082.1

    Status: VALIDATED

    Source sequence(s)
    BC050051, DB506492
    Consensus CDS
    CCDS42145.1
    UniProtKB/Swiss-Prot
    Q86XT9, Q8WVV8
    UniProtKB/TrEMBL
    A0A024R618
    Related
    ENSP00000279396.6, ENST00000279396.11
    Conserved Domains (1) summary
    pfam14940
    Location:48169
    TMEM219; Transmembrane 219
  2. NM_001369688.1NP_001356617.1  insulin-like growth factor-binding protein 3 receptor isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC093512, AC120114
    UniProtKB/Swiss-Prot
    Q8WVV8
    UniProtKB/TrEMBL
    A0A024R618
    Related
    ENSP00000457492.1, ENST00000566848.5
    Conserved Domains (1) summary
    pfam14940
    Location:48169
    TMEM219; Transmembrane 219
  3. NM_001369689.1NP_001356618.1  insulin-like growth factor-binding protein 3 receptor isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC093512, AC120114
    Related
    ENSP00000459732.2, ENST00000575829.6
    Conserved Domains (1) summary
    pfam14940
    Location:48169
    TMEM219; Transmembrane 219
  4. NM_001369690.1NP_001356619.1  insulin-like growth factor-binding protein 3 receptor isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC093512, AC120114
    Conserved Domains (1) summary
    pfam14940
    Location:48169
    TMEM219; Transmembrane 219
  5. NM_194280.4NP_919256.1  insulin-like growth factor-binding protein 3 receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_919256.1

    Status: VALIDATED

    Source sequence(s)
    AC093512, AC120114
    Consensus CDS
    CCDS42145.1
    UniProtKB/Swiss-Prot
    Q86XT9, Q8WVV8
    UniProtKB/TrEMBL
    A0A024R618
    Related
    ENSP00000388485.2, ENST00000414689.6
    Conserved Domains (1) summary
    pfam14940
    Location:48169
    TMEM219; Transmembrane 219

RNA

  1. NR_161465.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093512, AC120114
  2. NR_161466.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093512, AC120114

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    29962079..29973048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433622.1XP_047289578.1  insulin-like growth factor-binding protein 3 receptor isoform X1

    UniProtKB/Swiss-Prot
    Q8WVV8
    UniProtKB/TrEMBL
    A0A024R618
  2. XM_005255123.2XP_005255180.1  insulin-like growth factor-binding protein 3 receptor isoform X1

    See identical proteins and their annotated locations for XP_005255180.1

    UniProtKB/Swiss-Prot
    Q86XT9, Q8WVV8
    UniProtKB/TrEMBL
    A0A024R618
    Conserved Domains (1) summary
    pfam14940
    Location:48169
    TMEM219; Transmembrane 219

RNA

  1. XR_007064854.1 RNA Sequence

  2. XR_007064853.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    30244712..30255683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)