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Ccnd1 cyclin D1 [ Mus musculus (house mouse) ]

Gene ID: 12443, updated on 17-Jan-2023

Summary

Official Symbol
Ccnd1provided by MGI
Official Full Name
cyclin D1provided by MGI
Primary source
MGI:MGI:88313
See related
Ensembl:ENSMUSG00000070348 AllianceGenome:MGI:88313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cD1; CycD1; Cyl-1; PRAD1; bcl-1
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity; protein kinase activity; and protein kinase binding activity. Involved in negative regulation of epithelial cell differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including endoplasmic reticulum unfolded protein response; gland development; and positive regulation of mammary gland epithelial cell proliferation. Located in bicellular tight junction; cytoplasm; and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal cancer; hematologic cancer (multiple); invasive lobular carcinoma; and von Hippel-Lindau disease. Orthologous to human CCND1 (cyclin D1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 58.4), adrenal adult (RPKM 54.1) and 27 other tissues See more
Orthologs
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Genomic context

See Ccnd1 in Genome Data Viewer
Location:
7 F5; 7 88.92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144483668..144493568, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (144929931..144939831, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39119 Neighboring gene ABCE maturation factor Neighboring gene brain cytoplasmic RNA 1 Neighboring gene predicted gene, 46023 Neighboring gene predicted gene 45181

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
involved_in Leydig cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lactation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver regeneration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mammary gland alveolus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mammary gland epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mammary gland epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mitotic G1 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mammary gland epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within re-entry into mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to UV-A ISO
Inferred from Sequence Orthology
more info
 
involved_in response to leptin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organonitrogen compound ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
part_of cyclin D1-CDK4 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of cyclin D1-CDK4 complex ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379248.1NP_001366177.1  G1/S-specific cyclin-D1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC161763
    Conserved Domains (2) summary
    cd20573
    Location:3151
    CYCLIN_CCND1_rpt1; first cyclin box found in G1/S-specific cyclin-D1 (CCND1)
    cd20576
    Location:156287
    CYCLIN_CCND1_rpt2; second cyclin box found in G1/S-specific cyclin-D1 (CCND1)
  2. NM_007631.3NP_031657.1  G1/S-specific cyclin-D1 isoform 2

    See identical proteins and their annotated locations for NP_031657.1

    Status: VALIDATED

    Source sequence(s)
    AC161763
    Consensus CDS
    CCDS22055.1
    UniProtKB/Swiss-Prot
    P25322
    UniProtKB/TrEMBL
    A0A8C6IEV7, Q790L7
    Related
    ENSMUSP00000091495.5, ENSMUST00000093962.5
    Conserved Domains (2) summary
    cd20573
    Location:3151
    CYCLIN_CCND1_rpt1; first cyclin box found in G1/S-specific cyclin-D1 (CCND1)
    cd20576
    Location:156265
    CYCLIN_CCND1_rpt2; second cyclin box found in G1/S-specific cyclin-D1 (CCND1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    144483668..144493568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)