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Serpina6 serine (or cysteine) peptidase inhibitor, clade A, member 6 [ Mus musculus (house mouse) ]

Gene ID: 12401, updated on 8-Feb-2024

Summary

Official Symbol
Serpina6provided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade A, member 6provided by MGI
Primary source
MGI:MGI:88278
See related
Ensembl:ENSMUSG00000060807 AllianceGenome:MGI:88278
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cbg
Summary
This gene encodes a protein that belongs to the serpin (serine protease inhibitor) family. The encoded protein is an alpha-globulin with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors. [provided by RefSeq, Sep 2015]
Expression
Biased expression in liver E14.5 (RPKM 537.1), liver E14 (RPKM 488.5) and 1 other tissue See more
Orthologs
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Genomic context

See Serpina6 in Genome Data Viewer
Location:
12 E; 12 52.98 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103612889..103623477, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103646630..103657218, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16 Neighboring gene predicted gene, 46373 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 1F

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables steroid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables steroid binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables steroid binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within glucocorticoid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
corticosteroid-binding globulin
Names
serine (or cysteine) proteinase inhibitor, clade A, member 6
serpin A6
transcortin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007618.3NP_031644.1  corticosteroid-binding globulin precursor

    See identical proteins and their annotated locations for NP_031644.1

    Status: REVIEWED

    Source sequence(s)
    AA230586, AC125360, AK145842, BY090546
    Consensus CDS
    CCDS26135.1
    UniProtKB/Swiss-Prot
    Q06770
    UniProtKB/TrEMBL
    Q3UKW1
    Related
    ENSMUSP00000044033.7, ENSMUST00000044159.7
    Conserved Domains (1) summary
    smart00093
    Location:43396
    SERPIN; SERine Proteinase INhibitors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    103612889..103623477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)