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Cbfa2t2 CBFA2/RUNX1 translocation partner 2 [ Mus musculus (house mouse) ]

Gene ID: 12396, updated on 4-Dec-2022

Summary

Official Symbol
Cbfa2t2provided by MGI
Official Full Name
CBFA2/RUNX1 translocation partner 2provided by MGI
Primary source
MGI:MGI:1333833
See related
Ensembl:ENSMUSG00000038533 AllianceGenome:MGI:1333833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MTGR1; Cbfa2t2h; A430091M07; C330013D05Rik
Summary
Enables transcription corepressor activity. Involved in intestinal epithelial cell differentiation and negative regulation of Notch signaling pathway. Acts upstream of or within epithelial cell differentiation and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; blastocyst; brain; genitourinary system; and sensory organ. Orthologous to human CBFA2T2 (CBFA2/RUNX1 partner transcriptional co-repressor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 10.6), CNS E14 (RPKM 10.3) and 28 other tissues See more
Orthologs
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Genomic context

See Cbfa2t2 in Genome Data Viewer
Location:
2; 2 H1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (154278018..154381276)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (154436098..154539356)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1461 Neighboring gene predicted gene, 39962 Neighboring gene predicted gene, 52564 Neighboring gene zinc finger, FYVE domain containing 21 pseudogene Neighboring gene RIKEN cDNA 1700003F12 gene Neighboring gene N-terminal EF-hand calcium binding protein 3 Neighboring gene actin-like 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein CBFA2T2
Names
CBFA2T2 identified gene homolog
MTG8-like protein
MTG8-related protein 1
core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285446.1NP_001272375.1  protein CBFA2T2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and uses a downstream start codon compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL772292
    Conserved Domains (3) summary
    pfam01753
    Location:281317
    zf-MYND; MYND finger
    pfam08788
    Location:105171
    NHR2; NHR2 domain like
    cl27055
    Location:212280
    MutS_III; MutS domain III
  2. NM_009823.1NP_033953.1  protein CBFA2T2 isoform 2

    See identical proteins and their annotated locations for NP_033953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AK040403, AK148027, BC064679
    Consensus CDS
    CCDS50764.1
    UniProtKB/Swiss-Prot
    O70374
    UniProtKB/TrEMBL
    A0A0R4J1D5, A0A6P5R1W0, Q3UGB2
    Related
    ENSMUSP00000105347.2, ENSMUST00000109725.8
    Conserved Domains (4) summary
    pfam01753
    Location:497533
    zf-MYND; MYND finger
    pfam07531
    Location:106192
    TAFH; NHR1 homology to TAF
    pfam08788
    Location:322388
    NHR2; NHR2 domain like
    cl27055
    Location:433496
    MutS_III; MutS domain III
  3. NM_172860.2NP_766448.1  protein CBFA2T2 isoform 1

    See identical proteins and their annotated locations for NP_766448.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AK148027, BC064679
    Consensus CDS
    CCDS16932.1
    UniProtKB/Swiss-Prot
    O70374, Q6P288
    UniProtKB/TrEMBL
    A0A6P5RB76, Q3UGB2
    Related
    ENSMUSP00000043087.9, ENSMUST00000045270.15
    Conserved Domains (4) summary
    pfam01753
    Location:498534
    zf-MYND; MYND finger
    pfam07531
    Location:106192
    TAFH; NHR1 homology to TAF
    pfam08788
    Location:322388
    NHR2; NHR2 domain like
    cl27055
    Location:429497
    MutS_III; MutS domain III

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    154278018..154381276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157841.1XP_036013734.1  protein CBFA2T2 isoform X6

    Related
    ENSMUSP00000118371.2, ENSMUST00000137526.2
    Conserved Domains (3) summary
    PRK00409
    Location:161229
    PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
    pfam08788
    Location:54120
    NHR2; NHR2 domain like
    pfam01753
    Location:230266
    zf-MYND; MYND finger
  2. XM_006498642.3XP_006498705.1  protein CBFA2T2 isoform X4

    Conserved Domains (4) summary
    PRK00409
    Location:255323
    PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
    pfam01753
    Location:324360
    zf-MYND; MYND finger
    pfam07531
    Location:106191
    TAFH; NHR1 homology to TAF
    pfam08788
    Location:171214
    NHR2; NHR2 domain like
  3. XM_036157840.1XP_036013733.1  protein CBFA2T2 isoform X5

    Conserved Domains (4) summary
    PRK00409
    Location:259322
    PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
    pfam08788
    Location:171214
    NHR2; NHR2 domain like
    pfam01753
    Location:323359
    zf-MYND; MYND finger
    pfam07531
    Location:106191
    TAFH; NHR1 homology to TAF
  4. XM_006498641.2XP_006498704.1  protein CBFA2T2 isoform X2

    Conserved Domains (4) summary
    PRK00409
    Location:381449
    PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
    pfam01753
    Location:450486
    zf-MYND; MYND finger
    pfam07531
    Location:58147
    TAFH; NHR1 homology to TAF
    pfam08788
    Location:274340
    NHR2; NHR2 domain like
  5. XM_030247023.1XP_030102883.1  protein CBFA2T2 isoform X3

    Conserved Domains (4) summary
    PRK00409
    Location:385448
    PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
    pfam01753
    Location:449485
    zf-MYND; MYND finger
    pfam07531
    Location:58147
    TAFH; NHR1 homology to TAF
    pfam08788
    Location:274340
    NHR2; NHR2 domain like
  6. XM_006498640.4XP_006498703.1  protein CBFA2T2 isoform X1

    See identical proteins and their annotated locations for XP_006498703.1

    UniProtKB/Swiss-Prot
    O70374
    UniProtKB/TrEMBL
    A0A8C6MP91
    Conserved Domains (4) summary
    PRK00409
    Location:409477
    PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
    pfam01753
    Location:478514
    zf-MYND; MYND finger
    pfam07531
    Location:86175
    TAFH; NHR1 homology to TAF
    pfam08788
    Location:302368
    NHR2; NHR2 domain like